ArticleCell reports2012
Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Subcellular Enrichment Patterns of New Genes in Drosophila Evolution.Molecular biology and evolution · 2025Article
- Evolution of retrocopies in the context of HUSH silencing.Biology direct · 2024Article
- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- Protein evidence of unannotated ORFs ineLife · 2022Article
- A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number.Genetics · 2022Article
- Ancestry analysis indicates two different sets of essential genes in eukaryotic model species.Functional & integrative genomics · 2021Article
- Article
- Young genes have distinct gene structure, epigenetic profiles, and transcriptional regulation.Genome research · 2018Article
- Gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions.Nature ecology & evolution · 2018Article
- New genes often acquire male-specific functions but rarely become essential inGenes & development · 2017Article
- Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster.Genome biology and evolution · 2017Article
- Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.BMC genomics · 2016Article
- Altered Transcription and Neofunctionalization of Duplicated Genes Rescue the Harmful Effects of a Chimeric Gene inThe Plant cell · 2016Article
- Emergence and Evolution of Hominidae-Specific Coding and Noncoding Genomic Sequences.Genome biology and evolution · 2016Article
- Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes.Genome biology and evolution · 2015Article
- Integrative analysis of young genes, positively selected genes and lncRNAs in the development of Drosophila melanogaster.BMC evolutionary biology · 2014Article
- New gene evolution in the bonus-TIF1-γ/TRIM33 family impacted the architecture of the vertebrate dorsal-ventral patterning network.Molecular biology and evolution · 2014Article
- New genes as drivers of phenotypic evolution.Nature reviews. Genetics · 2013Review
- New gene evolution: little did we know.Annual review of genetics · 2013Review
- Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain.The EMBO journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The evolution of the brain and behavior are coupled puzzles. The genetic bases for brain evolution are widely debated, yet whether newly evolved genes impact the evolution of the brain and behavior is vaguely understood. Here, we show that during recent evolution in Drosophila, new genes have frequently acquired neuronal expression, particularly in the mushroom bodies. Evolutionary signatures combined with expression profiling showed that natural selection influenced the evolution of young genes expressed in the brain, notably in mushroom bodies. Case analyses showed that two young retrogenes are expressed in the olfactory circuit and facilitate foraging behavior. Comparative behavioral analysis revealed divergence in foraging behavior between species. Our data suggest that during adaptive evolution, new genes gain expression in specific brain structures and evolve new functions in neural circuits, which might contribute to the phenotypic evolution of animal behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.