ArticleCell reports2012
Mutation hot spots in yeast caused by long-range clustering of homopolymeric sequences.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes.Genes & development · 2026Article
- Short tandem repeats delineate gene bodies across eukaryotes.Nature communications · 2024Article
- MutLα suppresses error-prone DNA mismatch repair and preferentially protects noncoding DNA from mutations.The Journal of biological chemistry · 2024Article
- Cellular Responses to Widespread DNA Replication Stress.International journal of molecular sciences · 2023Review
- Heterogeneous Mutation Rates and Spectra in Yeast Hybrids.Genome biology and evolution · 2021Article
- Stability across the Whole Nuclear Genome in the Presence and Absence of DNA Mismatch Repair.Cells · 2021Review
- Pervasive function and evidence for selection across standing genetic variation in S. cerevisiae.Nature communications · 2019Article
- Article
- Comparative Genomics of Two SequentialG3 (Bethesda, Md.) · 2017Article
- Extremely Rare Polymorphisms in Saccharomyces cerevisiae Allow Inference of the Mutational Spectrum.PLoS genetics · 2017Article
- Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4.Genome research · 2016Article
- The Effect of Local Sequence Context on Mutational Bias of Genes Encoded on the Leading and Lagging Strands.Current biology : CB · 2016Article
- The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.PLoS genetics · 2015Article
- A Genetic Incompatibility Accelerates Adaptation in Yeast.PLoS genetics · 2015Article
- Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects.Nucleic acids research · 2015Article
- Eukaryotic Mismatch Repair in Relation to DNA Replication.Annual review of genetics · 2015Review
- Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition.Genome research · 2014Article
- Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.Genetics · 2014Article
- Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Evolutionary theory assumes that mutations occur randomly in the genome; however, studies performed in a variety of organisms indicate the existence of context-dependent mutation biases. Sources of mutagenesis variation across large genomic contexts (e.g., hundreds of bases) have not been identified. Here, we use high-coverage whole-genome sequencing of a conditional mismatch repair mutant line of diploid yeast to identify mutations that accumulated after 160 generations of growth. The vast majority of the mutations accumulated as insertion/deletions (in/dels) in homopolymeric [poly(dA:dT)] and repetitive DNA tracts. Surprisingly, the likelihood of an in/del mutation in a given poly(dA:dT) tract is increased by the presence of nearby poly(dA:dT) tracts in up to a 1,000 bp region centered on the given tract. Our work suggests that specific mutation hot spots can contribute disproportionately to the genetic variation that is introduced into populations and provides long-range genomic sequence context that contributes to mutagenesis.
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