Evidence map›Paper›PMID 22831916›Full record

Trial reportIntegrative cancer therapies2013

Effects of a physical activity behavior change intervention on inflammation and related health outcomes in breast cancer survivors: pilot randomized trial.

Laura Q Rogers, Amanda Fogleman, Rita Trammell, Patricia Hopkins-Price, Sandy Vicari, Krishna Rao, Billie Edson, Steven Verhulst, Kerry S Courneya, Karen Hoelzer

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Integrative cancer therapies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00640666 (Changes in Cancer-related Cytokines After Participation in a Physical Activity Behavior Change Intervention), which is not on this map. Cited by 78 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 21 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00640666 nacompletednot on this map

Changes in Cancer-related Cytokines After Participation in a Physical Activity Behavior Change Intervention (CICK Study)

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2008 to 2015Enrolled30ConditionsBreast CancerArmsExercise Behavior Change
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 21 syntheses or guidelines pooled it, 126 citations in OpenAlex.

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  12. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  13. Effects of physical activity on sleep problems in breast cancer survivors: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  14. Effects of Diet and Exercise-Induced Weight Loss on Biomarkers of Inflammation in Breast Cancer Survivors: A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
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  17. Efficacy of Exercise Therapy on Cardiorespiratory Fitness in Patients With Cancer: A Systematic Review and Meta-Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2018
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  19. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
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  20. Survivorship: sleep disorders, version 1.2014.Journal of the National Comprehensive Cancer Network : JNCCN · 2014
    Guideline

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Laura Q RogersSouthern Illinois University (SIU) School of Medicine, Springfield, IL 62794-9636, USA. lrogers@siumed.edu
Amanda Fogleman
Rita Trammell
Patricia Hopkins-Price
Sandy Vicari
Krishna Rao
Billie Edson
Steven Verhulst
Kerry S Courneya
Karen Hoelzer
Southern Illinois University School of Medicine · USSpringfield Clinic · USUniversity of Alberta · CA

Funding

Enhancing physical activity after breast cancer diagnosis: randomized trialR01CA136859 · NCI · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI ROGERS, LAURA Q · 2009 to 2012
$2.6M
Physical activity benefits after breast cancer: exploring cytokine mechanismsR21CA135017 · NCI · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI ROGERS, LAURA Q · 2010 to 2011
$343k
NCI NIH HHS 1R21CA135017NCI NIH HHS 5R01CA136859NCI NIH HHS R01 CA136859NCI NIH HHS R21 CA135017
6 · The paper itself

Abstract

backgroundThe goal of this pilot study was to determine the magnitude and direction of intervention effect sizes for inflammatory-related serum markers and relevant health outcomes among breast cancer survivors (BCSs) receiving a physical activity behavior change intervention compared with usual care.

methodsThis randomized controlled trial enrolled 28 stage I, II, or IIIA BCSs who were post-primary treatment and not regular exercisers. Participants were assigned to either a 3-month physical activity behavior change intervention group (ING) or usual care group (UCG). Intervention included supervised aerobic (150 weekly minutes, moderate-intensity) and resistance (2 sessions per week) exercise that gradually shifted to home-based exercise. Outcomes were assessed at baseline and 3 months.

resultsCardiorespiratory fitness significantly improved in the ING versus the UCG (between-group difference = 3.8 mL/kg/min; d = 1.1; P = .015). Self-reported sleep latency was significantly reduced in the ING versus the UCG (between group difference = -0.5; d = -1.2; P = .02) as was serum leptin (between-group difference = -9.0 ng/mL; d = -1.0; P = .031). Small to medium nonsignificant negative effect sizes were noted for interleukin (IL)-10 and tumor necrosis factor (TNF)-α and ratios of IL-6 to IL-10, IL-8 to IL-10, and TNF-α to IL-10, whereas nonsignificant positive effect sizes were noted for IL-6 and high-molecular-weight adiponectin.

conclusionsPhysical activity behavior change interventions in BCSs can achieve large effect size changes for several health outcomes. Although effect sizes for inflammatory markers were often small and not significant, changes were in the hypothesized direction for all except IL-6 and IL-10.

Indexed as

Health BehaviorAdultAgedBreast NeoplasmsExercise TherapyFemaleHealth StatusHumansInflammationMiddle AgedMotor ActivityPilot ProjectsSurvivorsTreatment Outcomecytokineexerciseinflammationinterventiononcologysurvivorship

Identifiers

PMID22831916
PMCPMC3909487
OpenAlexW2065311246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.