Evidence map›Paper›PMID 22831182›Full record

Trial reportDiabetes, obesity & metabolism2013

Adherence to a low-fat vs. low-carbohydrate diet differs by insulin resistance status.

A D McClain, J J Otten, E B Hekler, C D Gardner

Registry-linked trialOpen access · greenAbstract readComparative StudyLetterRandomized Controlled Trial
In one paragraph

Trial report in Diabetes, obesity & metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02519309 (Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02519309 nacompletednot on this mapstarted 2015, after this paper: background citation

Dietary Intervention in Type-2 Diabetics and Pre-Diabetics Emphasizing Personalized Carbohydrate Intake

TypeinterventionalSponsorVirta HealthRan2015 to 2021Enrolled465ConditionsDiabetes Mellitus, Type 2, Pre-diabetes, Metabolic SyndromeArmsVirta Program
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Review
  10. Should carbohydrate-modified diets be the first option for weight loss in people with impaired glucose metabolism? A scoping review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

A D McClain
J J Otten
E B Hekler
C D Gardner
Arizona State University · USPalo Alto University · USStanford Medicine · USStanford University · US

Funding

XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · NCRR · STANFORD UNIVERSITY · PI VAN MEURS, KRISA PAGE · 1985 to 2008
$32.4M
CARDIOVASCULAR DISEASE PREVENTION TRAINING PROGRAMT32HL007034 · NHLBI · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 1985 to 2020
$8.7M
Benefits &Risks of Popular Weight Loss DietsR21AT001098 · NCCIH · STANFORD UNIVERSITY · PI GARDNER, CHRISTOPHER D · 2002 to 2003
$393k
NCCIH NIH HHS R21 AT001098NCRR NIH HHS M01 RR000070NCRR NIH HHS M01-RR00070NHLBI NIH HHS 5 T32 HL 007034NHLBI NIH HHS T32 HL007034
6 · The paper itself

Abstract

Previous research shows diminished weight loss success in insulin-resistant (IR) women assigned to a low-fat (LF) diet compared to those assigned to a low-carbohydrate (LC) diet. These secondary analyses examined the relationship between insulin-resistance status and dietary adherence to either a LF-diet or LC-diet among 81 free-living, overweight/obese women [age = 41.9 ± 5.7 years; body mass index (BMI) = 32.6 ± 3.6 kg/m(2)]. This study found differential adherence by insulin-resistance status only to a LF-diet, not a LC-diet. IR participants were less likely to adhere and lose weight on a LF-diet compared to insulin-sensitive (IS) participants assigned to the same diet. There were no significant differences between IR and IS participants assigned to LC-diet in relative adherence or weight loss. These results suggest that insulin resistance status may affect dietary adherence to weight loss diets, resulting in higher recidivism and diminished weight loss success of IR participants advised to follow LF-diets for weight loss.

Indexed as

Diet, Carbohydrate-RestrictedDiet, Fat-RestrictedInsulin ResistanceWeight LossAdultAnalysis of VarianceBody CompositionBody Mass IndexDietary CarbohydratesDietary FatsDiet, ReducingFemaleHumansObesityPatient ComplianceDietary CarbohydratesDietary Fats

Identifiers

PMID22831182
PMCPMC3504183
OpenAlexW2154024513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.