ArticleJournal of neuroinflammation2012
Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.
Article in Journal of neuroinflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Research progress on the interaction between multiple organ-brain axes and perioperative neurocognitive disorders: a narrative review.Frontiers in aging neuroscience · 2025Review
- Non-invasive vagus nerve stimulation in anti-inflammatory therapy: mechanistic insights and future perspectives.Frontiers in neuroscience · 2024Review
- Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications.Frontiers in aging neuroscience · 2023Review
- Vagus Nerve Stimulation with Mild Stimulation Intensity Exerts Anti-Inflammatory and Neuroprotective Effects in Parkinson's Disease Model Rats.Biomedicines · 2021Article
- Growth differentiation factor 15 as a potential therapeutic for treating obesity.Molecular metabolism · 2021Review
- Vagus nerve stimulation ameliorates L-NAME-induced preeclampsia-like symptoms in rats through inhibition of the inflammatory response.BMC pregnancy and childbirth · 2021Article
- Randomized Cross Over Study Assessing the Efficacy of Non-invasive Stimulation of the Vagus Nerve in Patients With Axial Spondyloarthritis Resistant to Biotherapies: The ESNV-SPA Study Protocol.Frontiers in human neuroscience · 2021Article
- Vagus nerve stimulation in pregnant rats and effects on inflammatory markers in the brainstem of neonates.Pediatric research · 2018Article
- Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis.Frontiers in physiology · 2018Article
- The role of neutrophil granulocytes in immune-to-brain communication.Temperature (Austin, Tex.) · 2018Review
- Modulatory effects of vagal stimulation on neurophysiological parameters and the cellular immune response in the rat brain during systemic inflammation.Intensive care medicine experimental · 2016Article
- The role of the gut-brain axis in alcohol use disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2016Review
- Assessment of Cardiovascular Parameters during Meditation with Mental Targeting in Varsity Swimmers.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Vagus Nerve Stimulation for Treatment of Inflammation: Systematic Review of Animal Models and Clinical Studies.Bioelectronic medicine · 2016Article
- The interface between cholinergic pathways and the immune system and its relevance to arthritis.Arthritis research & therapy · 2015Review
- Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock.Intensive care medicine experimental · 2014Article
- Reflex control of inflammation by sympathetic nerves, not the vagus.The Journal of physiology · 2014Article
- Proposed toxic and hypoxic impairment of a brainstem locus in autism.International journal of environmental research and public health · 2013Article
- Transcranial doppler assessment of cerebral perfusion in critically ill septic patients: a pilot study.Annals of intensive care · 2013Article
- Mortality and suicide risk in treatment-resistant depression: an observational study of the long-term impact of intervention.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn sepsis syndromes the severity of the inflammation triggers microvascular dysfunction and early organ failure. We studied the effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculatory integrity in an endotoxinemic rat model.
methodsIn both control and endotoxinemic (5 mg/kg lipopolysaccharide i.v.) rats, the effect of cervical bilateral vagotomy with or without left-sided distal vagus nerve stimulation were compared to non-vagotomized, nonstimulated group (sham). Neurovascular coupling was analyzed by electrical forepaw stimulation, EEG, and cortical laser-Doppler flow recording. Resting cerebral blood flow, evoked potentials and hemodynamic responses, were obtained over a period of 4.5 hours. Regulation of the nitric oxide system (iNOS expression and nitrite/nitrate measurements), cytokines (IFN-γ, TNF-α, IL-6, IL-10), hypoxic and apoptosis signaling molecules (HIF-2α, Bax) were measured at the end of experiments.
resultsIn endotoxinemic rats, vagus nerve stimulation tended to increase anti-inflammatory cytokine levels and resulted in a stabile hemodynamic response (28 ± 13%; versus baseline). Vagotomized animals incurred a pro-inflammatory response (7 ± 4%; P < 0.0001 versus baseline) and produced more HIF-2α than vagotomized vagus nerve stimulated (VNS) animals. Evoked potential amplitudes were stabilized in VNS (15 ± 7 μV; n.s. versus baseline) as compared to vagotomised rats (8 ± 5 μV; P < 0.001 versus baseline). However, no effects were observed on apoptosis markers or nitric oxide levels.
conclusionsVagus nerve stimulation in endotoxinemic rats had a positive effect on neurovascular coupling and stabilized evoked potentials.
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