ArticlePloS one2012
Wallerian degeneration in central nervous system: dynamic associations between diffusion indices and their underlying pathology.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Research hotspots and trends in the application of diffusion tensor imaging in ischemic stroke: a bibliometric analysis (2003-2024).Frontiers in neurology · 2025Pooled it
- Longitudinal automated fiber quantification reveals corticospinal tract dynamics and prognostic significance after primary basal ganglia hemorrhage.Neuroradiology · 2026Article
- Cerebellar peduncle damage in Langerhans cell histiocytosis-associated neurodegenerative disease revealed by diffusion tensor imaging.Neuroradiology · 2024Article
- Quantification of Diffusion Magnetic Resonance Imaging for Prognostic Prediction of Neonatal Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2024Review
- Delayed Diffusion Restriction of Wallerian Degeneration.Neurocritical care · 2023Article
- Globally altered microstructural properties and network topology in Rasmussen's encephalitis.Brain communications · 2023Article
- Development of a composite diffusion tensor imaging score correlating with short-term neurological status in neonatal hypoxic-ischemic encephalopathy.Frontiers in neuroscience · 2022Article
- Impact of the acquisition protocol on the sensitivity to demyelination and axonal loss of clinically feasible DWI techniques: a simulation study.Magma (New York, N.Y.) · 2021Article
- For Better or for Worse: A Look Into Neutrophils in Traumatic Spinal Cord Injury.Frontiers in cellular neuroscience · 2021Review
- Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain.Science advances · 2020Article
- Brain white matter changes in asymptomatic carriers of Leber's hereditary optic neuropathy.Journal of neurology · 2019Article
- Fractional Anisotropy of Thalamic Nuclei Is Associated With Verticality Misperception After Extra-Thalamic Stroke.Frontiers in neurology · 2019Article
- Differential involvement of rubral branches in chronic capsular and pontine stroke.NeuroImage. Clinical · 2019Article
- Quantitative assessment of demyelination in ischemic stroke in vivo using macromolecular proton fraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Brain White Matter Impairment in Patients with Spinal Cord Injury.Neural plasticity · 2017Article
- Diffusional kurtosis imaging in evaluating the secondary change of corticospinal tract after unilateral cerebral infarction.American journal of translational research · 2017Article
- What drives progressive motor deficits in patients with acute pontine infarction?Neural regeneration research · 2015Review
- Decoding diffusivity in multiple sclerosis: analysis of optic radiation lesional and non-lesional white matter.PloS one · 2015Article
- Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging.International journal of ophthalmology · 2015Article
- White matter changes linked to visual recovery after nerve decompression.Science translational medicine · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough diffusion tensor imaging has been used to monitor Wallerian degeneration, the exact relationship between the evolution of diffusion indices and its underlying pathology, especially in central nervous system, remains largely unknown. Here we aimed to address this question using a cat Wallerian degeneration model of corticospinal tract. METHODOLOGY/PRINCIPAL
findingsTwenty-five domestic mature Felis catus were included in the present study. The evolution of diffusion indices, including mean diffusivity (MD), fractional anisotropy (FA), primary (λ1) and transverse eigenvalues (λ23) of the degenerated corticospinal tract, were observed at baseline (before modeling) and at 2, 4, 6, 8, 10, 15, 20, 25, 30, 45 and 60 days after modeling in 4 cats. Pathological examinations were performed at eight time points mentioned above. Wallerian degeneration can be detected as early as the 2nd day after modeling by both diffusion tensor imaging and pathology. According to the evolution of diffusion indices, Wallerian degeneration can be classified into 2 stages. During the early stage (within 8 days after modeling), progressive disintegration of axons and myelin sheaths underlies the decreases in FA and λ1 and the increase in λ23. However, during the late stage (after 8 days), the gradual increases in FA, MD and λ1 and the unchanged λ23 seem to be a comprehensive reflection of the pathological processes including microglia activation, myelin clearance, and astrocytosis. CONCLUSIONS/SIGNIFICANCE: Our findings help the understanding of the altered diffusion indices in the context of pathology and suggest that diffusion tensor imaging has the potential to monitor the processes of Wallerian degeneration in the central nervous system in vivo after acute damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.