Evidence map›Paper›PMID 22829821›Full record

ArticleAdvances in virology2012

Human herpesviridae methods of natural killer cell evasion.

Carl I Odom, David C Gaston, James M Markert, Kevin A Cassady

Abstract read
In one paragraph

Article in Advances in virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Infectious Triggers of Cytokine Storm Syndromes: Herpes Virus Family (Non-EBV).Advances in experimental medicine and biology · 2024
    Review
  2. Article
  3. Article
  4. Review
  5. A Valine Mismatch at Position 129 ofInternational journal of molecular sciences · 2018
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carl I OdomSchool of Medicine, University of Alabama at Birmingham, 1600 6th Avenue South, CHB 118C, Birmingham, AL 35233-1701, USA.
David C Gaston
James M Markert
Kevin A Cassady

Funding

Virus Production CoreP01CA071933 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WEICHSELBAUM, RALPH R · 1997 to 2013
$14.5M
UAB Short-Term Research Training in Health Professional Schools (SHRT)T35HL007473 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAM M GEISLER · 1985 to 2026
$4.0M
CONTEMPORARY THERAPEUTICS FOR ANAPLASTIC GLIOMASP20CA151129 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GILLESPIE, G. YANCEY · 2011 to 2013
$2.3M
Training Program in Brain Tumor BiologyT32NS048039 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2007 to 2017
$2.0M
UAB Center for Clinical and Translational Science (CCTS) T32 (TL1)TL1RR025775 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2008 to 2011
$334k
NCI NIH HHS P01 CA071933NCI NIH HHS P20 CA151129NCRR NIH HHS TL1 RR025775NHLBI NIH HHS T35 HL007473NINDS NIH HHS T32 NS048039
6 · The paper itself

Abstract

Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. These methods include interference with the ligands on infected cell surfaces that bind NK cell activating or inhibitory receptors. This paper summarizes the most extensively studied NK cell receptor/ligand pairs and then describes the methods of NK cell evasion used by all eight herpesviruses through these receptors and ligands. Although great strides have been made in elucidating their mechanisms, there is still a disparity between viruses in the amount of knowledge regarding innate immune evasion. Further research of herpesvirus innate immune evasion can provide insight for circumventing viral mechanisms in future therapies.

Identifiers

PMID22829821
PMCPMC3399383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.