ArticleGastroenterology research and practice2012
Recent Insights into Antibiotic Resistance in Helicobacter pylori Eradication.
Article in Gastroenterology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Article
- Identification of Antimicrobial Peptide Variants From Lactobacillus spp. Against H. pylori-Mediated Gastric Cancer: An In-Silico Approach.The Korean journal of helicobacter and upper gastrointestinal research · 2026Article
- Revealing the therapeutic properties of gut microbiota: transforming cancer immunotherapy from basic to clinical approaches.Medical oncology (Northwood, London, England) · 2024Review
- Antibiotic-induced ROS-mediated Fur allosterism contributes toAntimicrobial agents and chemotherapy · 2024Article
- Article
- Susceptibility patterns and virulence genotypes ofWorld journal of gastroenterology · 2023Article
- Advances in metal graphitic nanocapsules for biomedicine.Exploration (Beijing, China) · 2022Review
- Metal Graphitic Nanocapsules for Theranostics in Harsh Conditions.Frontiers in chemistry · 2022Review
- The Efficacy, Safety, and Tolerability of Levofloxacin Quadruple Therapy forEvidence-based complementary and alternative medicine : eCAM · 2022Article
- The influence of P-glycoprotein expression in the standard treatment of Helicobacter pylori infection in Sprague Dawley rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2021Article
- In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori.Nature communications · 2021Article
- Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors.The Journal of experimental medicine · 2021Article
- Article
- Trend of changes in antibiotic resistance inTherapeutic advances in gastroenterology · 2020Article
- Primary Resistance Pattern ofInfection and drug resistance · 2020Review
- Review
- Nanotechnology intervention of the microbiome for cancer therapy.Nature nanotechnology · 2019Review
- Molecular characterization and prevalence of antibiotic resistance inInfection and drug resistance · 2019Article
- Punctual mutations inWorld journal of gastroenterology · 2018Article
- Molecular Patterns of Resistance AmongFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics have been useful in the treatment of H. pylori-related benign and malignant gastroduodenal diseases. However, emergence of antibiotic resistance often decreases the eradication rates of H. pylori infections. Many factors have been implicated as causes of treatment failure, but the main antibiotic resistance mechanisms described to date are due to point mutations on the bacterial chromosome, a consequence of a significantly phenotypic variation in H. pylori. The prevalence of antibiotic (e.g., clarithromycin, metronidazole, tetracycline, amoxicillin, and furazolidone) resistance varies among different countries; it appears to be partly determined by geographical factors. Since the worldwide increase in the rate of antibiotic resistance represents a problem of relevance, some studies have been performed in order to identify highly active and well-tolerated anti-H. pylori therapies including sequential, concomitant quadruple, hybrid, and quadruple therapy. These represent a promising alternatives in the effort to overcome the problem of resistance. The aim of this paper is to review the current status of antibiotic resistance in H. pylori eradication, highlighting the evolutionary processes in detail at alternative approaches to treatment in the past decade. The underlying resistance mechanisms will be also followed.
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Registered trials
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