ReviewExperimental diabetes research2012
The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration.
Review in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Markers of Oxidative Stress and Inflammation in Patients With Intestinal Metaplasia and Metabolic Syndrome
Clinical and Biochemical Study of the Effects of Rosuvastatin, Vitamin E, and N-Acetyl Cysteine on Patients With Non-alcoholic Steatohepatitis: a Randomized Controlled Trial
Who cites it
74 citing papers in PubMed, 199 citations in OpenAlex.
- The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and Inflammation in Metabolic Syndrome.Nutrients · 2022Trial
- Phytochemicals and REDOX Modulation: Molecular Mechanisms, Clinical Relevance, and Therapeutic Perspectives.Antioxidants (Basel, Switzerland) · 2026Review
- Sex-specific obesity paradox and type 2 myocardial infarction in acute ischemic stroke (AIS) patients.Biology of sex differences · 2026Article
- Article
- Two Faces of Indole-3-Carbinol-Analysis of Lipid Peroxidation Induced by Fenton Reaction Substrates in Porcine Ovary and Kidney Homogenates.Nutrients · 2025Article
- MiR221/222 in the conditioned medium of adipose-derived stem cells attenuates particulate matter and high-fat diet-induced cardiac apoptosis.Stem cell research & therapy · 2025Article
- Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis-A Narrative Review.Journal of clinical medicine · 2025Review
- Associations between cardiometabolic index with kidney stones: evidence from NHANES 2007-2018.Frontiers in endocrinology · 2025Article
- Association Between Metabolic Syndrome and Cardiac Autonomic Nervous Function and Cardiorespiratory Fitness in Older Adults: A Retrospective Observational Study with Propensity Score Overlap Weighting.Clinical interventions in aging · 2025Observational
- Composite dietary antioxidant index is associated with the prevalence of metabolic syndrome in females: results from NHANES 2011-2016.Frontiers in nutrition · 2025Article
- The Cumulative and Single Effect of 12 Aldehydes Concentrations on Cardiovascular Diseases: An Analysis Based on Bayesian Kernel Machine Regression and Weighted Logistic Regression.Reviews in cardiovascular medicine · 2024Article
- A new perspective of frozen shoulder pathology; the interplay between the brain and the immune system.Frontiers in physiology · 2024Review
- Personal exposure of PMEnvironmental science and pollution research international · 2023Observational
- Therapeutic Potential for Beta-3 Adrenoreceptor Agonists in Peripheral Arterial Disease and Diabetic Foot Ulcers.Biomedicines · 2023Review
- Long-term air pollution exposure and diabetes risk in American older adults: A national secondary data-based cohort study.Environmental pollution (Barking, Essex : 1987) · 2023Article
- Article
- Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome.Frontiers in endocrinology · 2023Article
- Perioperative selenium administration in cardiac surgery patients, a way out to reduce post surgical adversities? A meta analysis.Frontiers in cardiovascular medicine · 2023Review
- Associations between ambient air pollution, obesity, and serum vitamin D status in the general population of Korean adults.BMC public health · 2022Article
- Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The metabolic syndrome affects 30% of the US population with increasing prevalence. In this paper, we explore the relationship between the metabolic syndrome and the incidence and severity of cardiovascular disease in general and coronary artery disease (CAD) in particular. Furthermore, we look at the impact of metabolic syndrome on outcomes of coronary revascularization therapies including CABG, PTCA, and coronary collateral development. We also examine the association between the metabolic syndrome and its individual component pathologies and oxidative stress. Related, we explore the interaction between the main external sources of oxidative stress, cigarette smoke and air pollution, and metabolic syndrome and the effect of this interaction on CAD. We discuss the apparent lack of positive effect of antioxidants on cardiovascular outcomes in large clinical trials with emphasis on some of the limitations of these trials. Finally, we present evidence for successful use of antioxidant properties of pharmacological agents, including metformin, statins, angiotensin II type I receptor blockers (ARBs), and angiotensin II converting enzyme (ACE) inhibitors, for prevention and treatment of the cardiovascular complications of the metabolic syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.