ArticlePLoS genetics2012
The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 100 citations in OpenAlex.
- Bridging precision agriculture and human medicine through comparative genetics.Nature reviews. Genetics · 2026Review
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- Assessing the genotype effects on performance and meat quality traits of Nigerian indigenous chicken varieties and a commercial breed for sustainable poultry production.Tropical animal health and production · 2025Article
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- The feather's multi-functional structure across nano to macro scales inspires hierarchical design.Journal of the Royal Society, Interface · 2025Review
- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- Current Understanding of Feather Keratin and Keratinase and Their Applications in Biotechnology.Biochemistry research international · 2025Review
- A molecular mechanism for bright color variation in parrots.Science (New York, N.Y.) · 2024Article
- Modification of Keratin Integrations and the Associated Morphogenesis in Frizzling Chicken Feathers.Biology · 2024Article
- Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm.Chinese journal of physics · 2023Article
- Review
- Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response during Wound Repair.The Journal of investigative dermatology · 2023Article
- Altered hair root gene expression profiles highlight calcium signaling and lipid metabolism pathways to be associated with curly hair initiation and maintenance in Mangalitza pigs.Frontiers in genetics · 2023Article
- Effects of a FCBP gene polymorphism, location, and sex on Young's modulus of the tenth primary feather in racing pigeons.Scientific reports · 2022Article
- Analysis and comparison of protein secondary structures in the rachis of avian flight feathers.PeerJ · 2022Article
- Making region-specific integumentary organs in birds: evolution and modifications.Current opinion in genetics & development · 2021Review
- Direct allele introgression into pure chicken breeds using Sire Dam Surrogate (SDS) mating.Nature communications · 2021Article
- Microbial enzymes catalyzing keratin degradation: Classification, structure, function.Biotechnology advances · 2020Review
- Genome-Wide Association Study and Transcriptome Differential Expression Analysis of the Feather Rate in Shouguang Chickens.Frontiers in genetics · 2020Article
- Mid-Cretaceous amber inclusions reveal morphogenesis of extinct rachis-dominated feathers.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
Feathers have complex forms and are an excellent model to study the development and evolution of morphologies. Existing chicken feather mutants are especially useful for identifying genetic determinants of feather formation. This study focused on the gene F, underlying the frizzle feather trait that has a characteristic curled feather rachis and barbs in domestic chickens. Our developmental biology studies identified defects in feather medulla formation, and physical studies revealed that the frizzle feather curls in a stepwise manner. The frizzle gene is transmitted in an autosomal incomplete dominant mode. A whole-genome linkage scan of five pedigrees with 2678 SNPs revealed association of the frizzle locus with a keratin gene-enriched region within the linkage group E22C19W28_E50C23. Sequence analyses of the keratin gene cluster identified a 69 bp in-frame deletion in a conserved region of KRT75, an α-keratin gene. Retroviral-mediated expression of the mutated F cDNA in the wild-type rectrix qualitatively changed the bending of the rachis with some features of frizzle feathers including irregular kinks, severe bending near their distal ends, and substantially higher variations among samples in comparison to normal feathers. These results confirmed KRT75 as the F gene. This study demonstrates the potential of our approach for identifying genetic determinants of feather forms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.