ArticlePLoS pathogens2012
Monocytes regulate the mechanism of T-cell death by inducing Fas-mediated apoptosis during bacterial infection.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Melatonin attenuates Mycoplasma pneumoniae-Induced Inflammation and barrier dysfunction by CXCL10/TLR4/STAT1 axis.Cell communication and signaling : CCS · 2026Article
- Combined single-cell transcriptome and immune repertoire analysis reveals hepatic and renal immune injury by heat stroke.JCI insight · 2026Article
- Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia.Immunity · 2022Article
- Macrophage LC3-associated phagocytosis is an immune defense againstProceedings of the National Academy of Sciences of the United States of America · 2020Article
- 27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression.Cancer letters · 2020Article
- Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice.Scientific reports · 2020Article
- The Critical Roles and Mechanisms of Immune Cell Death in Sepsis.Frontiers in immunology · 2020Review
- Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells duringInnate immunity · 2019Article
- The investigation of immunomodulatory effects of adipose tissue mesenchymal stem cell educated macrophages on the CD4 T cells.Immunobiology · 2019Article
- Excretory-secretory product of third-stage Gnathostoma spinigerum larvae induces apoptosis in human peripheral blood mononuclear cells.Parasitology research · 2017Article
- Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes.Pathogens and disease · 2017Article
- A Novel Function for theFrontiers in immunology · 2017Article
- Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release.Scientific reports · 2016Article
- Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice.Cell host & microbe · 2016Article
- Insights into the apoptotic death of immune cells in sepsis.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2015Review
- Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8⁺ T cell response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- An ahemolytic pneumolysin of Streptococcus pneumoniae manipulates human innate and CD4⁺ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner.The Journal of infectious diseases · 2014Article
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- The Pla protease of Yersinia pestis degrades fas ligand to manipulate host cell death and inflammation.Cell host & microbe · 2014Article
- Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incompletely characterized. T-cell death in cultures of peripheral blood mononuclear cells (PBMC) showed 'classic' features of apoptosis following exposure to pneumococci. Conversely, purified CD3(+) T-cells cultured with pneumococci demonstrated necrosis with membrane permeabilization. The death of purified CD3(+) T-cells was not inhibited by necrostatin, but required the bacterial toxin pneumolysin. Apoptosis of CD3(+) T-cells in PBMC cultures required 'classical' CD14(+) monocytes, which enhanced T-cell activation. CD3(+) T-cell death was enhanced in HIV-seropositive individuals. Monocyte-mediated CD3(+) T-cell apoptotic death was Fas-dependent both in vitro and in vivo. In the early stages of the T-cell dependent host response to pneumococci reduced Fas ligand mediated T-cell apoptosis was associated with decreased bacterial clearance in the lung and increased bacteremia. In summary monocytes converted pathogen-associated necrosis into Fas-dependent apoptosis and regulated levels of activated T-cells at sites of acute bacterial infection. These changes were associated with enhanced bacterial clearance in the lung and reduced levels of invasive pneumococcal disease.
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