ArticleMediators of inflammation2012
Inflammatory marker sTREM-1 reflects the clinical stage and respiratory tract obstruction in allergic asthma bronchiale patients and correlates with number of neutrophils.
Article in Mediators of inflammation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- sTREM-1, HMGB1, CRP, PCT, sCD14-ST, IL-6, IL-10, sHLA-G, and Vitamin D in Relation to Clinical Scores and Survival in SIRS/Sepsis.Biomedicines · 2025Article
- Training associated alterations in equine respiratory immunity using a multiomics comparative approach.Scientific reports · 2022Article
- Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study.Journal of innate immunity · 2019Article
- Soluble Triggering Receptor Expressed on Myeloid Cells 1 in lung cancer.Scientific reports · 2018Article
- Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma.BMC genomics · 2017Article
- Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma.Inflammation · 2017Review
- Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control.American journal of respiratory and critical care medicine · 2017Article
- TREM-1low is a novel characteristic for tumor-associated macrophages in lung cancer.Oncotarget · 2016Article
- Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end-products in allergic airway inflammation.Expert review of respiratory medicine · 2016Review
- Evaluation and Validation of the Detection of soluble Triggering Receptor Expressed on Myeloid Cells 1 by Enzyme-linked immunosorbent Assay.Scientific reports · 2015Article
- TREM-2 Receptor Expression Increases with 25(OH)D Vitamin Serum Levels in Patients with Pulmonary Sarcoidosis.Mediators of inflammation · 2015Article
- Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?Frontiers in microbiology · 2014Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The knowledge that asthma is an inflammatory disorder has prompted us to investigate the plasma levels of a new inflammatory marker sTREM-1 that is released from the surfaces of activated neutrophils and monocytes. The plasma levels of sTREM-1 were analysed by a sandwich ELISA test in the cohort of 76 patients with allergic asthma bronchiale and 39 healthy controls. Our results revealed more than 3.5 times higher levels of sTREM-1 in AB patients (92.3 pg/mL ± 125.6) compared with healthy subjects (25.7 pg/mL ± 9.2; P = 0.0001). Higher levels of sTREM-1 were found also in patients with exacerbated AB (170.5 pg/mL ± 78.2) compared with nonexacerbated AB patients (59.1 ± 78.2; P < 0.0001), patients with respiratory tract obstruction (176.4 pg/mL ± 177.8), than those without obstruction (51.99 pg/mL ± 64.0; P < 0.0001) and patients with anti-IgE therapy (P < 0.0001). Levels of sTREM-1 correlated with number of leucocytes (P = 0.002), and absolute number of neutrophils (P = 0.001). Elevated plasma levels of sTREM-1 reflect the severity, state of exacerbation, presence of respiratory tract obstruction in AB patients and together with increased number of neutrophils point to the role of neutrophils in inflammation accompanying AB.
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