ReviewExperimental biology and medicine (Maywood, N.J.)2012
DNA damage and neurotoxicity of chronic alcohol abuse.
Review in Experimental biology and medicine (Maywood, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Identifying risk factors of young-onset dementia and evaluating evidence hierarchy: a meta-analysis and umbrella review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Timeless and Stainless Alcohol: Concentric Waves from Its Oxidative Metabolism and Related Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Review
- Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study.Nature communications · 2025Article
- Global burden of lip and oral cavity cancer attributable to high alcohol consumption from 1990 to 2021.Frontiers in nutrition · 2025Article
- Quercetin Protects against Ethanol-induced Neurodegeneration in Adult Rat Cortex.Current neuropharmacology · 2025Article
- Activation of STING signaling aggravates chronic alcohol exposure-induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis.CNS neuroscience & therapeutics · 2024Article
- The interaction effects of age, APOE and common environmental risk factors on human brain structure.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Roles of NFR2-Regulated Oxidative Stress and Mitochondrial Quality Control in Chronic Liver Diseases.Antioxidants (Basel, Switzerland) · 2023Review
- Opioid induces increased DNA damage in prefrontal cortex and nucleus accumbens.Pharmacology, biochemistry, and behavior · 2023Article
- Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment.Endocrine reviews · 2022Review
- Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Article
- Calculated identification of mutator-derived lncRNA signatures of genomic instability to predict the clinical outcome of muscle-invasive bladder cancer.Cancer cell international · 2021Article
- Association of Alcohol-Induced Loss of Consciousness and Overall Alcohol Consumption With Risk for Dementia.JAMA network open · 2020Article
- Article
- Neurochemical Evidence of Preclinical and Clinical Reports on Target-Based Therapy in Alcohol Used Disorder.Neurochemical research · 2020Review
- Alcohol and Dementia - What is the Link? A Systematic Review.Neuropsychiatric disease and treatment · 2020Review
- Alcohol use and dementia: a systematic scoping review.Alzheimer's research & therapy · 2019Article
- Review
- Turnover of histones and histone variants in postnatal rat brain: effects of alcohol exposure.Clinical epigenetics · 2017Article
- Chronic Alcohol Exposure Decreases 53BP1 Protein Levels Leading to a Defective DNA Repair in Cultured Primary Cortical Neurons.Neurotoxicity research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic alcohol abuse results in a variety of pathological effects including damage to the brain. The causes of alcohol-induced brain pathology are presently unclear. Several mechanisms of pathogenicity of chronic alcoholism have been proposed, including accumulation of DNA damage in the absence of repair, resulting in genomic instability and death of neurons. Genomic instability is a unified genetic mechanism leading to a variety of neurodegenerative disorders. Ethanol also likely interacts with various metabolic pathways, including one-carbon metabolism (OCM). OCM is critical for the synthesis of DNA precursors, essential for DNA repair, and as a methyl donor for various methylation events, including DNA methylation. Both DNA repair and DNA methylation are critical for maintaining genomic stability. In this review, we outline the role of DNA damage and DNA repair dysfunction in chronic alcohol-induced neurodegeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.