ArticlePsychopharmacology2013
Common influences of non-competitive NMDA receptor antagonists on the consolidation and reconsolidation of cocaine-cue memory.
Article in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- A randomized, placebo-controlled laboratory study of the effects of D-cycloserine on sexual memory consolidation in women.Psychopharmacology · 2020Trial
- Assessing the translational feasibility of pharmacological drug memory reconsolidation blockade with memantine in quitting smokers.Psychopharmacology · 2015Trial
- The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults.Experimental brain research · 2023Article
- Fluctuating NMDA Receptor Subunit Levels in Perirhinal Cortex Relate to Their Dynamic Roles in Object Memory Destabilization and Reconsolidation.International journal of molecular sciences · 2020Article
- Molecular and circuit mechanisms regulating cocaine memory.Cellular and molecular life sciences : CMLS · 2020Review
- Sobriety and Satiety: Is NAD+ the Answer?Antioxidants (Basel, Switzerland) · 2020Review
- Deletion of Glycogen Synthase Kinase-3β in DBiological psychiatry · 2020Article
- Alcohol inhibits morphine/cocaine reward memory acquisition and reconsolidation in rats.Psychopharmacology · 2020Article
- Activation of GSK3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling.Journal of neurochemistry · 2019Article
- Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Combined administration of MK-801 and cycloheximide produces a delayed potentiation of fear discrimination memory extinction.Behavioral neuroscience · 2018Article
- Infralimbic GluN2A-Containing NMDA Receptors Modulate Reconsolidation of Cocaine Self-Administration Memory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- NMDAR dependent intracellular responses associated with cocaine conditioned place preference behavior.Behavioural brain research · 2017Article
- Metabolic shift of the kynurenine pathway impairs alcohol and cocaine seeking and relapse.Psychopharmacology · 2016Article
- Effects of Trace Amine-associated Receptor 1 Agonists on the Expression, Reconsolidation, and Extinction of Cocaine Reward Memory.The international journal of neuropsychopharmacology · 2016Article
- Variations in the stimulus salience of cocaine reward influences drug-associated contextual memory.Addiction biology · 2016Article
- Retrieval-induced NMDA receptor-dependent Arc expression in two models of cocaine-cue memory.Neurobiology of learning and memory · 2014Article
- Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition.Psychopharmacology · 2014Article
- Memory reconsolidation in aversive and appetitive settings.Frontiers in behavioral neuroscience · 2013Review
- Addiction: a drug-induced disorder of memory reconsolidation.Current opinion in neurobiology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleEnvironmental stimuli or contexts previously associated with rewarding drugs contribute importantly to relapse among addicts, and research has focused on neurobiological processes maintaining those memories. Much research shows contributions of cell surface receptors and intracellular signaling pathways in maintaining associations between rewarding drugs (e.g., cocaine) and concurrent cues/contexts; these memories can be degraded at the time of their retrieval through reconsolidation interference. Much less studied is the consolidation of drug-cue memories during their acquisition.
objectiveThe present experiments use the cocaine-conditioned place preference (CPP) paradigm in rats to directly compare, in a consistent setting, the effects of N-methyl-D-aspartate (NMDA) glutamate receptor antagonists MK-801 and memantine on the consolidation and reconsolidation of cocaine-cue memories.
methodsFor the consolidation studies, animals were systemically administered MK-801 or memantine immediately following training sessions. To investigate the effects of these NMDA receptor antagonists on the retention of previously established cocaine-cue memories, animals were systemically administered MK-801 or memantine immediately after memory retrieval.
resultsAnimals given either NMDA receptor antagonist immediately following training sessions did not establish a preference for the cocaine-paired compartment. Post-retrieval administration of either NMDA receptor antagonist attenuated the animals' preference for the cocaine-paired compartment. Furthermore, animals given NMDA receptor antagonists post-retrieval showed a blunted response to cocaine-primed reinstatement.
conclusionsUsing two distinct NMDA receptor antagonists in a common setting, these findings demonstrate that NMDA receptor-dependent processes contribute both to the consolidation and reconsolidation of cocaine-cue memories, and they point to the potential utility of treatments that interfere with drug-cue memory reconsolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.