ArticleInternational journal of colorectal disease2012
Metachronous carcinomas in colorectum and its clinicopathological significance.
Article in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Various clinicopathological features of patients with metachronous colorectal cancer in relation to different diagnostic intervals.International journal of colorectal disease · 2018Article
- Novel FAM134B mutations and their clinicopathological significance in colorectal cancer.Human genetics · 2017Article
- Feasibility and safety of laparoscopic surgery for metachronous colorectal cancer.Surgery today · 2015Article
- Synchronous colorectal cancer: clinical, pathological and molecular implications.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study was designed to examine the significance of colorectal metachronous carcinoma in a large cohort of patients.
methodsOver a mean follow-up period of 10 years, the clinicopathological features, microsatellite instability (MSI) and clinical follow-up of 56 patients with metachronous colorectal carcinoma were analysed.
resultsThe prevalence of metachronous colorectal carcinoma was 2.1 %. The metachronous colorectal carcinomas appeared between 7 and 246 months (mean = 66 months) after surgical resection of the index colorectal carcinomas. Thirty-six per cent (n = 20) of the metachronous carcinoma occurred more than 5 years after the operation of the index carcinoma. Of the 56 patients, 20 % (n = 11) of the metachronous colorectal carcinomas were mucinous adenocarcinoma. Cancers detected in the secondary operations (metachronous colorectal carcinomas), when compared with the primary index cancers, were smaller, showed higher proportions of mucinous adenocarcinoma and more often located in the proximal colon. Patients with metachronous colorectal cancers had higher prevalence of mucinous adenocarcinoma, loss of staining for MSI markers and better survival rates than other patients with colorectal cancers.
conclusionsPatients with metachronous colorectal carcinomas have characteristic features, and attention to these features is important for better management of this group of cancer.
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