ArticleInternational journal of obesity (2005)2012
Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model.
Article in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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24 citing papers in PubMed, 35 citations in OpenAlex.
- CDK5 Inhibits Synphilin-1 Ubiquitination and Basal Mitophagy: Implications for Parkinson's Disease.International journal of molecular sciences · 2025Article
- The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity.Current obesity reports · 2025Review
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- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- AMPK signaling mediates synphilin-1-induced hyperphagia and obesity inJournal of cell science · 2021Article
- Molecular and cytological analysis of widely-used Gal4 driver lines for Drosophila neurobiology.BMC genetics · 2020Article
- Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation.International journal of molecular sciences · 2020Article
- Transcriptomic and microRNA analyses of gene networks regulated by eicosapentaenoic acid in brown adipose tissue of diet-induced obese mice.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2018Article
- Endurance exercise prevents high-fat-diet induced heart and mobility premature aging andOncotarget · 2018Article
- Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans.PLoS genetics · 2017Article
- A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.Nature communications · 2017Article
- Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation.Cell death & disease · 2016Article
- Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson's disease models.Human molecular genetics · 2016Article
- Splicing variants of porcine synphilin-1.Meta gene · 2015Article
- CCK Response Deficiency in Synphilin-1 Transgenic Mice.PloS one · 2015Article
- Regulation of body fat in Caenorhabditis elegans.Annual review of physiology · 2015Review
- From fat fruit fly to human obesity.Physiology & behavior · 2014Review
- Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster.The Journal of experimental biology · 2014Article
- Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimsThe pathogenesis of obesity remains incompletely understood. Drosophila have conserved neuroendocrine and digestion systems with human and become an excellent system for studying energy homeostasis. Here, we reported a novel obesity Drosophila model, in which expression of human protein, synphilin-1 (SP1), in neurons fosters positive energy balance. SUBJECTS AND
methodsTo further understand the actions of SP1 in energy balance control, the upstream activation sequence UAS/GAL4 system was used to generate human SP1 transgenic Drosophila. We characterized a human SP1 transgenic Drosophila by assessing SP1 expression, fat lipid deposition, food intake and fly locomotor activity to determine the major behavioral changes and their consequences in the development of the obesity-like phenotype.
resultsOverexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity. SP1 increased the levels of triacylglycerol, and the size of fat body cells and lipid droplets, indicating that SP1 increased lipid-fat disposition. Survival studies showed that SP1 transgenic flies were more resistant to food deprivation. SP1 regulated lipin gene expression that may participate in SP1-induced fat deposition and starvation resistance.
conclusionThese studies demonstrate that SP1 expression affects energy homeostasis in ways that enhance positive energy balance and provide a useful obesity model for future pathogenesis and therapeutic studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.