ArticleEnvironmental science and pollution research international2011
Effects of perinatal exposure to bisphenol A and di(2-ethylhexyl)-phthalate on gonadal development of male mice.
Article in Environmental science and pollution research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review on the adverse health effects of di-2-ethylhexyl phthalate.Environmental science and pollution research international · 2016Pooled it
- Exposure Levels and Health Risks of Phthalate Alternatives: A Urinary Metabolite Study.Environment & health (Washington, D.C.) · 2025Article
- Bisphenol A and its effects on the systemic organs of children.European journal of pediatrics · 2021Review
- The effects of bisphenol A given in ovo on bursa of Fabricius development and percentage of acid phosphatase positive lymphocyte in chicken.Environmental science and pollution research international · 2021Article
- Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis.Environmental science and pollution research international · 2020Article
- Bisphenols and Leydig Cell Development and Function.Frontiers in endocrinology · 2020Review
- Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats.Iranian journal of basic medical sciences · 2018Article
- Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis.PloS one · 2018Article
- Associations between Urinary Phthalate Metabolites and Serum Anti-Müller Hormone Levels in U.S. Men Based on National Health and Nutrition Examination Survey 2003-2004.International journal of environmental research and public health · 2017Article
- Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Bisphenol A exposure during early development induces sex-specific changes in adult zebrafish social interactions.Journal of toxicology and environmental health. Part A · 2015Article
- Prenatal Exposure to DEHP Affects Spermatogenesis and Sperm DNA Methylation in a Strain-Dependent Manner.PloS one · 2015Article
- Mouse strain does not influence the overall effects of bisphenol a-induced toxicity in adult antral follicles.Biology of reproduction · 2013Article
- Studies in experimental autoimmune encephalomyelitis do not support developmental bisphenol a exposure as an environmental factor in increasing multiple sclerosis risk.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals.Expert opinion on therapeutic targets · 2013Review
- Gestational bisphenol A exposure and testis development.Endocrine disruptors (Austin, Tex.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this study, we investigated the effects of maternal transfer of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) during gestational and weaning periods on gonadal development of male offspring.
methodsPregnant CD-1 mice were administered by gavages in corn oil with 0.1, 1, or 10 mg/kg/day of BPA and DEHP from gestational days (GD1-21) to the weaning period (postnatal days (PND) 1-21).
resultsOur data indicated that the exposure significantly reduced the male-to-female sex ratio and the sizes of the gonads of male pups as recorded at PND15. The testes of the perinatally exposed male pups were developed less and the expression levels of testicular anti-mullerian hormone, androgen receptor, cyclin A, and StAR were significantly lesser than the control male pups. The less developed testes were accompanied with significant reductions in the expression levels of Gnrh and Fsh at the hypothalamic-pituitary levels. The negative effects were found to be persistent in the sexually mature pups at PND42.
conclusionOur data reveal that the maternal transfer of BPA and DEHP may impose negative influence on the development and functions of the reproductive system of male pups.
Indexed as
Identifiers
22828881What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.