ArticleCellular and molecular life sciences : CMLS2012
Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.
Article in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 167 citations in OpenAlex.
- Article
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- Sex-specific metabolic regulation by the Drosophila RNA-binding protein Nab2.bioRxiv : the preprint server for biology · 2026Article
- Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin-Like Peptide in Bactrocera Dorsalis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual interference with host neuropeptide signaling allows parasitoid wasp to hijack host sugar metabolism.The EMBO journal · 2026Article
- Endocrine Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Article
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- A Peptidergic Neural System Connects the Circadian Clock to the Photoperiodic Control of Reproductive Diapause in the BugThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- CRISPR/Cas9-Mediated Knockout of theInsects · 2025Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Article
- A Head-Specific Transcriptomic Study Reveals Key Regulatory Pathways for Winter Diapause in the Mosquito Culex pipiens.Archives of insect biochemistry and physiology · 2025Article
- Article
- Neuronal expressions of Taxi and Adar are crucial in maintaining the lifespan ofJournal of genetics · 2025Article
- Synaptic connectome of the Drosophila circadian clock.Nature communications · 2024Article
- An evolutionarily conserved pathway mediated by neuroparsin-A regulates reproductive plasticity in ants.PLoS biology · 2024Article
- Short neuropeptide F in integrated insect physiology.Journal of Zhejiang University. Science. B · 2024Review
- Neuromodulators and neuroepigenetics of social behavior in ants.Annals of the New York Academy of Sciences · 2023Review
20 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin/IGF-like signaling regulates the development, growth, fecundity, metabolic homeostasis, stress resistance and lifespan in worms, flies and mammals. Eight insulin-like peptides (DILP1-8) are found in Drosophila. Three of these (DILP2, 3 and 5) are produced by a set of median neurosecretory cells (insulin-producing cells, IPCs) in the brain. Activity in the IPCs of adult flies is regulated by glucose and several neurotransmitters and neuropeptides. One of these, short neuropeptide F (sNPF), regulates food intake, growth and Dilp transcript levels in IPCs via the sNPF receptor (sNPFR1) expressed on IPCs. Here we identify a set of brain neurons that utilizes sNPF to activate the IPCs. These sNPF-expressing neurons (dorsal lateral peptidergic neurons, DLPs) also produce the neuropeptide corazonin (CRZ) and have axon terminations impinging on IPCs. Knockdown of either sNPF or CRZ in DLPs extends survival in flies exposed to starvation and alters carbohydrate and lipid metabolism. Expression of sNPF in DLPs in the sNPF mutant background is sufficient to rescue wild-type metabolism and response to starvation. Since CRZ receptor RNAi in IPCs affects starvation resistance and metabolism, similar to peptide knockdown in DLPs, it is likely that also CRZ targets the IPCs. Knockdown of sNPF, but not CRZ in DLPs decreases transcription of Dilp2 and 5 in the brain, suggesting different mechanisms of action on IPCs of the two co-released peptides. Our findings indicate that sNPF and CRZ co-released from a small set of neurons regulate IPCs, stress resistance and metabolism in adult Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.