Evidence map›Paper›PMID 22828728›Full record

ArticleMolecular bioSystems2012

A cardiac tissue-specific binding agent of troponin I.

Wael R Abd-Elgaliel, Ching-Hsuan Tung

Abstract read
In one paragraph

Article in Molecular bioSystems, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wael R Abd-ElgalielDepartment of Translational Imaging, Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, USA. ctung@tmhs.org
Ching-Hsuan Tung
Cornell University · US

Funding

Dendritic nanomedicine for cancer imaging and treatmentR01CA135312 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI TUNG, CHING-HSUAN · 2008 to 2012
$1.5M
NCI NIH HHS CA135312NCI NIH HHS R01 CA135312
6 · The paper itself

Abstract

A fluorescently labeled, biphenylalanine-rich peptide was identified as a should be cardiac troponin I-specific binding agent with preferential staining affinity to myocardium tissues and extremely low staining to other stromal components. Fluorescence images demonstrate that this new peptide is an excellent contrast agent useful for examining troponin I structural distribution and expression density within heart tissue sections. It provides a clear contrast between myocardial cells and the surrounding collagen matrix.

Indexed as

Amino Acid SequenceAnimalsFluorescent DyesHistocytochemistryIndicators and ReagentsMiceMicroscopy, FluorescenceMolecular Sequence DataMuscle, SkeletalMyocardiumMyocytes, CardiacOligopeptidesProtein BindingTroponin IFluorescent DyesIndicators and ReagentsOligopeptidesTroponin I

Identifiers

PMID22828728
PMCPMC3430814
OpenAlexW2027670985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.