ArticleBiophysical journal2012
Label-free imaging of membrane potential using membrane electromotility.
Article in Biophysical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Spark or Sound: How Two Differing Explanatory Strategies Impact the Debate on the Physical Nature of Neuronal Excitability.Membranes · 2026Article
- Dynamic membrane changes and osmotic effects by sugar alcohols.NPJ science of food · 2025Article
- Fluorescence Imaging of Cell Membrane Potential: From Relative Changes to Absolute Values.International journal of molecular sciences · 2023Review
- Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics.Nature communications · 2022Article
- Ultra-parallel label-free optophysiology of neural activity.iScience · 2022Article
- Optical Electrophysiology: Toward the Goal of Label-Free Voltage Imaging.Journal of the American Chemical Society · 2021Article
- On the Coupling between Mechanical Properties and Electrostatics in Biological Membranes.Membranes · 2021Review
- Computational interference microscopy enabled by deep learning.APL photonics · 2021Article
- Detection of cellular micromotion by advanced signal processing.Scientific reports · 2020Article
- Reply to Farrell: Experimental evidence is the ultimate judge for model assumptions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mechanisms of Light-Induced Deformations in Photoreceptors.Biophysical journal · 2020Article
- The optoretinogram reveals the primary steps of phototransduction in the living human eye.Science advances · 2020Article
- High-speed interferometric imaging reveals dynamics of neuronal deformation during the action potential.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Picosecond-resolution phase-sensitive imaging of transparent objects in a single shot.Science advances · 2020Article
- Lipid Bilayer Thickness Measured by Quantitative DIC Reveals Phase Transitions and Effects of Substrate Hydrophilicity.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Plasmonic imaging of subcellular electromechanical deformation in mammalian cells.Journal of biomedical optics · 2019Article
- Axonal Computations.Frontiers in cellular neuroscience · 2019Review
- Imaging Action Potential in Single Mammalian Neurons by Tracking the Accompanying Sub-Nanometer Mechanical Motion.ACS nano · 2018Article
- Full-field interferometric imaging of propagating action potentials.Light, science & applications · 2018Article
- Label-free optical detection of action potential in mammalian neurons.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Electrical activity may cause observable changes in a cell's structure in the absence of exogenous reporter molecules. In this work, we report a low-coherence interferometric microscopy technique that can detect an optical signal correlated with the membrane potential changes in individual mammalian cells without exogenous labels. By measuring milliradian-scale phase shifts in the transmitted light, we can detect changes in the cells' membrane potential. We find that the observed optical signals are due to membrane electromotility, which causes the cells to deform in response to the membrane potential changes. We demonstrate wide-field imaging of the propagation of electrical stimuli in gap-junction-coupled cell networks. Membrane electromotility-induced cell deformation may be useful as a reporter of electrical activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.