ReviewFEBS letters2012
Yeast as a model to understand the interaction between genotype and the response to calorie restriction.
Review in FEBS letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The Effect of Different Substrates on the Morphological Features and Polyols Production ofMicroorganisms · 2022Article
- Evolution, Chance, and Aging.Frontiers in genetics · 2021Review
- Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging.Biomolecules · 2020Review
- Estimating network changes from lifespan measurements using a parsimonious gene network model of cellular aging.BMC bioinformatics · 2019Article
- Protein aggregation activates erratic stress response in dietary restricted yeast cells.Scientific reports · 2016Article
- The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects.Veterinary pathology · 2016Review
- Yeast Replicator: A High-Throughput Multiplexed Microfluidics Platform for Automated Measurements of Single-Cell Aging.Cell reports · 2015Article
- Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective.Neurochemistry international · 2015Review
- Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.Proceedings. Biological sciences · 2015Article
- Regulation of ribosomal DNA amplification by the TOR pathway.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae.The Journal of cell biology · 2015Article
- Yeast replicative aging: a paradigm for defining conserved longevity interventions.FEMS yeast research · 2014Review
- Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing.Experimental gerontology · 2013Review
- Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans.Longevity & healthspan · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Calorie restriction is reported to enhance survival and delay the onset of age-related decline in many different species. Several proteins have been proposed to play a role in mediating the response to calorie restriction, including the target of rapamycin kinase, sirtuins, and AMP kinase. An enhanced mechanistic understanding of calorie restriction has popularized the concept of "calorie restriction mimetics", drugs that mimic the beneficial effects of caloire restriction without requiring a reduction in nutrient intake. In theory, such drugs should delay the onset and progression of multiple age-related diseases, similar to calorie restriction in mammals. Despite the potential benefits of such calorie restriction mimetics, however, relatively little is known about the interaction between genetic variation and individual response to calorie restriction. Limited evidence from model systems indicates that genotype plays a large role in determining both the magnitude and direction of effect that calorie restriction has on longevity. Here we present an overview of these data from the perspective of using yeast as a model to study aging and describe an approach we are taking to further characterize the molecular mechanisms underlying genotype-dependent responses to calorie restriction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.