ArticleExperimental eye research2012
Oxygen consumption and distribution in the Long-Evans rat retina.
Article in Experimental eye research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Retinal Hypoxia: Relation to Blood Flow and Oxygen Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Macular Deep Capillary Plexus Ischemia as a Biomarker for Identifying Referable Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Ocular Microvascular Changes in Offspring Born to Mothers With Gestational Diabetes Mellitus: The Nanjing Eye Study.Translational vision science & technology · 2025Article
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- The Importance of Matching Optical Coherence Tomography Angiography Metrics to Diabetic Retinopathy Severity for Detecting Progression.Investigative ophthalmology & visual science · 2025Observational
- Superficial Retinal Intercapillary Oxygen Diffusion and Perfusion Deficit Alterations in Patients With Coronary Artery Disease.Investigative ophthalmology & visual science · 2025Article
- Longitudinal assessment of retinal and visual pathway electrophysiology and structure after high altitude exposure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Article
- Diabetes-Induced Changes of the Rat ERG in Relation to Hyperglycemia and Acidosis.Current eye research · 2024Article
- Oxygen profiles and oxygen consumption in the isolated mouse retina.Experimental eye research · 2023Article
- Extracellular KExperimental eye research · 2022Article
- Age dependence of retinal vascular plexus attenuation in the triple transgenic mouse model of Alzheimer's disease.Experimental eye research · 2022Article
- Uncoupling proteins in the mitochondrial defense against oxidative stress.Progress in retinal and eye research · 2021Review
- Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration.Experimental eye research · 2021Article
- Geometric Perfusion Deficits: A Novel OCT Angiography Biomarker for Diabetic Retinopathy Based on Oxygen Diffusion.American journal of ophthalmology · 2021Article
- Intravenous ketamine for long term anesthesia in rats.Heliyon · 2020Article
- Retinal capillary oximetry with visible light optical coherence tomography.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Improved Macular Capillary Flow on Optical Coherence Tomography Angiography After Panretinal Photocoagulation for Proliferative Diabetic Retinopathy.American journal of ophthalmology · 2019Article
- Diabetes Alters pH Control in Rat Retina.Investigative ophthalmology & visual science · 2019Article
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2 authors.
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Abstract
The purpose of this study was to investigate the oxygen distribution and consumption in the pigmented Long-Evans rat retina in vivo during dark and light adaptation, and to compare these results to previous work on cat and albino rat. Double-barreled microelectrodes recorded both intraretinal PO(2) depth profiles and the electroretinogram (ERG), which was used to identify the boundaries of the retina. Light adaptation decreased photoreceptor oxygen consumption per unit volume (Q(av)) from 3.0 ± 0.4 ml·100 g(-1) min(-1) (mean ± SEM) in darkness to 1.8 ± 0.2 ml·100 g(-1) min(-1) and increased minimum outer retinal PO(2) at the inner segments (P(min)) from 17.4 ± 3.0 to 29.9 ± 5.3 mmHg. The effects of light on outer retinal PO(2) and Q(av) were similar to those previously observed in cat, monkey, and albino rats; however, dark-adapted P(min) was higher in rat than cat. The parameters derived from fitting the oxygen diffusion model to the rat data were compared to those from cat. Oxygen consumption of the inner segments (Q(2)) and choroidal PO(2) (P(C)) in rat and cat were similar. P(min) was higher in rat than in cat for two reasons: first, rat photoreceptors have a shorter oxygen consuming region; and second, the retinal circulation supplied a greater fraction of consumed oxygen to rat photoreceptors. The average PO(2) across the inner retina (P(IR)) was not different in dark adaptation (25.4 ± 4.8 mmHg) and light adaptation (28.8 ± 5.4 mmHg) when measured from PO(2) profiles. However, with the microelectrode stationary at 9-18% retinal depth, a small consistent decrease in PO(2) occurred during illumination. Flickering light at 6 Hz decreased inner retinal PO(2) significantly more than an equivalent steady illumination, suggesting that changes in blood flow did not completely compensate for increased metabolism. This study comprehensively characterized rat retinal oxygenation in both light and dark, and determined the similarities and differences between rat and cat retinas.
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