Observational studyCritical care (London, England)2012
Ventilatory support in critically ill hematology patients with respiratory failure.
Observational study in Critical care (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Observational studies of early versus late salvage therapies in critical care exhibit intrinsic selection bias: two meta-analyses.Critical care (London, England) · 2025Pooled it
- Use of noninvasive ventilation in immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis.Critical care (London, England) · 2017Pooled it
- Noninvasive versus invasive mechanical ventilation for immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis.BMC pulmonary medicine · 2016Pooled it
- The use of high-flow nasal oxygen vs. standard oxygen therapy in hematological malignancy patients with acute respiratory failure in hematology wardsTurkish journal of medical sciences · 2021Trial
- Critically ill adult patients with acute leukemia: a systematic review and meta-analysis.Annals of intensive care · 2025Article
- First-Line Respiratory Support for Children With Hematologic Malignancy and Acute Respiratory Failure.Critical care explorations · 2024Article
- Differences in the relative importance of predictors of short- and long-term mortality among critically ill patients with cancer.Critical care science · 2024Article
- High-value care for critically ill oncohematological patients: what do we know thus far?Critical care science · 2023Review
- Risk factors for ICU mortality in patients with hematological malignancies: a singlecenter, retrospective cohort study from Turkey.Turkish journal of medical sciences · 2023Article
- Oxygenation strategy during acute respiratory failure in immunocompromised patients.Journal of intensive medicine · 2021Review
- Management strategy for hematological malignancy patients with acute respiratory failure.European journal of medical research · 2021Review
- Failure of Noninvasive Ventilation in Acute Respiratory Failure is Associated with Higher Mortality in Patients with Solid Tumors: A Retrospective Cohort Study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Review
- Epidemiology, Clinical Characteristics, and Prognostic Factors in Critically Ill Patients with Hematolymphoid Malignancy.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Factors associated with non-invasive mechanical ventilation failure in patients with hematological neoplasia and their association with outcomes.Journal of intensive care · 2020Article
- Observational
- Awake extracorporeal membrane oxygenation in immunosuppressed patients with severe respiratory failure-a stretch too far?Journal of thoracic disease · 2019Article
- Immunocompromised patients with acute respiratory distress syndrome: secondary analysis of the LUNG SAFE database.Critical care (London, England) · 2018Observational
- Risk factors for and prediction of mortality in critically ill medical-surgical patients receiving heparin thromboprophylaxis.Annals of intensive care · 2016Article
- High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study.Annals of intensive care · 2016Article
Corrections and comments
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Authors and funding
12 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHematology patients admitted to the ICU frequently experience respiratory failure and require mechanical ventilation. Noninvasive mechanical ventilation (NIMV) may decrease the risk of intubation, but NIMV failure poses its own risks.
methodsTo establish the impact of ventilatory management and NIMV failure on outcome, data from a prospective, multicenter, observational study were analyzed. All hematology patients admitted to one of the 34 participating ICUs in a 17-month period were followed up. Data on demographics, diagnosis, severity, organ failure, and supportive therapies were recorded. A logistic regression analysis was done to evaluate the risk factors associated with death and NIVM failure.
resultsOf 450 patients, 300 required ventilatory support. A diagnosis of congestive heart failure and the initial use of NIMV significantly improved survival, whereas APACHE II score, allogeneic transplantation, and NIMV failure increased the risk of death. The risk factors associated with NIMV success were age, congestive heart failure, and bacteremia. Patients with NIMV failure experienced a more severe respiratory impairment than did those electively intubated.
conclusionsNIMV improves the outcome of hematology patients with respiratory insufficiency, but NIMV failure may have the opposite effect. A careful selection of patients with rapidly reversible causes of respiratory failure may increase NIMV success.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.