Evidence map›Paper›PMID 22827862›Full record

ReviewAnnals of the New York Academy of Sciences2012

Interacting epidemics? Sleep curtailment, insulin resistance, and obesity.

Eliane A Lucassen, Kristina I Rother, Giovanni Cizza

Open access · bronzeAbstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Association between sleep duration and obesity in patients with type 2 diabetes: A longitudinal study.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Article
  8. Article
  9. Article
  10. Napping and Obesity in Adults - What do we Know?Current diabetes reports · 2024
    Review
  11. Article
  12. A social-ecological examination of sleep among Airmen in technical training.Military psychology : the official journal of the Division of Military Psychology, American Psychological Association · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors of Male Infertility.International journal of environmental research and public health · 2022
    Review
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Eliane A LucassenImmunogenetics Section, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. eliane.lucassen@nih.gov
Kristina I Rother
Giovanni Cizza
Leiden University Medical Center · NLNational Institutes of Health · US

Funding

Studies in Youths & Young Adults with Obesity & T2DM (07-DK-0115, 10-DK-0163)ZIADK047049 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REITMAN, MARC L · 2009 to 2019
$4.4M
Chronic Sleep deprivation as a risk factor for endocrine and immune changesZIADK047054 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CIZZA, GIOVANNI · 2009 to 2013
$1.9M
Sleep deprivation and narcolepsy as risk factors for increased body weightZIADK075002 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CIZZA, GIOVANNI · 2009 to 2013
$1.4M
Chronic sleep deprivation as a risk factor for metabolic syndrome and obesityZIADK075015 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CIZZA, GIOVANNI · 2009 to 2013
$1.4M
Intramural NIH HHS ZIA DK047054
6 · The paper itself

Abstract

In the last 50 years, the average self-reported sleep duration in the United States has decreased by 1.5-2 hours in parallel with an increasing prevalence of obesity and diabetes. Epidemiological studies and meta-analyses report a strong relationship between short or disturbed sleep, obesity, and abnormalities in glucose metabolism. This relationship is likely to be bidirectional and causal in nature, but many aspects remain to be elucidated. Sleep and the internal circadian clock influence a host of endocrine parameters. Sleep curtailment in humans alters multiple metabolic pathways, leading to more insulin resistance, possibly decreased energy expenditure, increased appetite, and immunological changes. On the other hand, psychological, endocrine, and anatomical abnormalities in individuals with obesity and/or diabetes can interfere with sleep duration and quality, thus creating a vicious cycle. In this review, we address mechanisms linking sleep with metabolism, highlight the need for studies conducted in real-life settings, and explore therapeutic interventions to improve sleep, with a potential beneficial effect on obesity and its comorbidities.

Indexed as

Energy MetabolismInsulin ResistanceObesityAdiponectinAppetiteDiabetes MellitusFemaleGhrelinGlucoseHumansLeptinMaleMelatoninRisk FactorsSleep DeprivationSleep Wake DisordersAdiponectinGhrelinGlucoseLeptinMelatonin

Identifiers

PMID22827862
PMCPMC3418485
OpenAlexW1711695767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.