ArticleBMC genomics2012
DNA repair and crossing over favor similar chromosome regions as discovered in radiation hybrid of Triticum.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Fine mapping KT1 on wheat chromosome 5A that conditions kernel dimensions and grain weight.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- High-resolution mapping of the pericentromeric region on wheat chromosome arm 5AS harbouring the Fusarium head blight resistance QTL Qfhs.ifa-5A.Plant biotechnology journal · 2018Article
- Identification and Validation of a New Source of Low Grain Cadmium Accumulation in Durum Wheat.G3 (Bethesda, Md.) · 2018Article
- Fast-forward genetics by radiation hybrids to saturate the locus regulating nuclear-cytoplasmic compatibility in Triticum.Plant biotechnology journal · 2016Article
- A High Resolution Radiation Hybrid Map of Wheat Chromosome 4A.Frontiers in plant science · 2016Article
- Radiation hybrid maps of the D-genome of Aegilops tauschii and their application in sequence assembly of large and complex plant genomes.BMC genomics · 2015Article
- Development of a D genome specific marker resource for diploid and hexaploid wheat.BMC genomics · 2015Article
- Radiation hybrid QTL mapping of Tdes2 involved in the first meiotic division of wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- A high density physical map of chromosome 1BL supports evolutionary studies, map-based cloning and sequencing in wheat.Genome biology · 2013Article
- A radiation hybrid map of chromosome 1D reveals synteny conservation at a wheat speciation locus.Functional & integrative genomics · 2013Article
- Physical mapping resources for large plant genomes: radiation hybrids for wheat D-genome progenitor Aegilops tauschii.BMC genomics · 2012Article
- Integrating cereal genomics to support innovation in the Triticeae.Functional & integrative genomics · 2012Review
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Authors and funding
21 authors at 10 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe uneven distribution of recombination across the length of chromosomes results in inaccurate estimates of genetic to physical distances. In wheat (Triticum aestivum L.) chromosome 3B, it has been estimated that 90% of the cross over events occur in distal sub-telomeric regions representing 40% of the chromosome. Radiation hybrid (RH) mapping which does not rely on recombination is a strategy to map genomes and has been widely employed in animal species and more recently in some plants. RH maps have been proposed to provide i) higher and ii) more uniform resolution than genetic maps, and iii) to be independent of the distribution patterns observed for meiotic recombination. An in vivo RH panel was generated for mapping chromosome 3B of wheat in an attempt to provide a complete scaffold for this ~1 Gb segment of the genome and compare the resolution to previous genetic maps.
resultsA high density RH map with 541 marker loci anchored to chromosome 3B spanning a total distance of 1871.9 cR was generated. Detailed comparisons with a genetic map of similar quality confirmed that i) the overall resolution of the RH map was 10.5 fold higher and ii) six fold more uniform. A significant interaction (r = 0.879 at p = 0.01) was observed between the DNA repair mechanism and the distribution of crossing-over events. This observation could be explained by accepting the possibility that the DNA repair mechanism in somatic cells is affected by the chromatin state in a way similar to the effect that chromatin state has on recombination frequencies in gametic cells.
conclusionsThe RH data presented here support for the first time in vivo the hypothesis of non-casual interaction between recombination hot-spots and DNA repair. Further, two major hypotheses are presented on how chromatin compactness could affect the DNA repair mechanism. Since the initial RH application 37 years ago, we were able to show for the first time that the iii) third hypothesis of RH mapping might not be entirely correct.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.