Trial reportAlcoholism, clinical and experimental research2013
Posttreatment low-risk drinking as a predictor of future drinking and problem outcomes among individuals with alcohol use disorders.
Trial report in Alcoholism, clinical and experimental research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02290223 (Patient Activation to Address Chronic Pain and Opioid Management in Primary Care), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patient Activation to Address Chronic Pain and Opioid Management in Primary Care
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Substance Use Disorder Treatment Outcomes: Methodological Overview of Metrics and Criteria.International journal of methods in psychiatric research · 2025Pooled it
- Systematic review of outcome domains and measures used in psychosocial and pharmacological treatment trials for cannabis use disorder.Drug and alcohol dependence · 2019Pooled it
- Predictors of abstinence, no heavy drinking days, and a 2-level reduction in World Health Organization drinking levels during treatment for alcohol use disorder in the COMBINE study.Alcoholism, clinical and experimental research · 2022Trial
- Combined analysis of the moderating effect of a GRIK1 polymorphism on the effects of topiramate for treating alcohol use disorder.Drug and alcohol dependence · 2021Trial
- Abstinence and low risk drinking during treatment: Association with psychosocial functioning, alcohol use, and alcohol problems 3 years following treatment.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2018Trial
- Effect of Varenicline Combined With Medical Management on Alcohol Use Disorder With Comorbid Cigarette Smoking: A Randomized Clinical Trial.JAMA psychiatry · 2018Trial
- Collaborative Care for Opioid and Alcohol Use Disorders in Primary Care: The SUMMIT Randomized Clinical Trial.JAMA internal medicine · 2017Trial
- Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study.Alcoholism, clinical and experimental research · 2017Trial
- Posttreatment Low-Risk Drinking as a Predictor of Future Drinking and Problem Outcomes Among Individuals with Alcohol Use Disorders: A 9-Year Follow-Up.Alcoholism, clinical and experimental research · 2017Trial
- Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels.Alcoholism, clinical and experimental research · 2017Trial
- Using contingency management procedures to reduce at-risk drinking in heavy drinkers.Alcoholism, clinical and experimental research · 2015Trial
- Type 2 Diabetes Health Care Outcomes for Patients with Alcohol Use Disorder Starting Addiction Treatment.Journal of general internal medicine · 2025Article
- Combination of Drugs in the Treatment of Alcohol Use Disorder: A Meta-Analysis and Meta-Regression Study.Brain sciences · 2025Review
- Patterns of drinking behavior around a treatment episode for alcohol use disorder: Predictions from pre-treatment measures.Alcohol, clinical & experimental research · 2023Article
- Resting state connectivity in people living with HIV before and after stopping heavy drinking.Frontiers in psychiatry · 2023Article
- Predictors of early and sustained cessation of heavy drinking over 5 years among adult primary care patients.Addiction (Abingdon, England) · 2022Article
- Within-AUD outpatient treatment heavy drinking transitions and associations with long-term outcomes.Drug and alcohol dependence · 2021Article
- World Health Organization risk drinking levels as a treatment outcome measure in topiramate trials.Alcoholism, clinical and experimental research · 2021Article
- Non-abstinent treatment outcomes for cannabis use disorder.Drug and alcohol dependence · 2021Article
- Are non-abstinent reductions in World Health Organization drinking risk level a valid treatment target for alcohol use disorders in adolescents with ADHD?Addictive behaviors reports · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundTreatment for alcohol disorders has traditionally been abstinence-oriented, but evaluating the merits of a low-risk drinking outcome as part of a primary treatment endpoint is a timely issue given new pertinent regulatory guidelines. This study explores a posttreatment low-risk drinking outcome as a predictor of future drinking and problem severity outcomes among individuals with alcohol use disorders in a large private, not for profit, integrated care health plan.
methodsStudy participants include adults with alcohol use disorders at 6 months (N = 995) from 2 large randomized studies. Logistic regression models were used to explore the relationship between past 30-day drinker status at 6 months posttreatment (abstinent [66%], low-risk drinking [14%] defined as nonabstinence and no days of 5+ drinking, and heavy drinking [20%] defined as 1 or more days of 5+ drinking) and 12-month outcomes, including drinking status and Addiction Severity Index measures of medical, psychiatric, family/social, and employment severity, controlling for baseline covariates.
resultsCompared to heavy drinkers, abstinent individuals and low-risk drinkers at 6 months were more likely to be abstinent or low-risk drinkers at 12 months (adj. ORs = 16.7 and 3.4, respectively; p < 0.0001); though, the benefit of abstinence was much greater than that of low-risk drinking. Compared to heavy drinkers, abstinent and low-risk drinkers were similarly associated with lower 12-month psychiatric severity (adj. ORs = 1.8 and 2.2, respectively, p < 0.01) and family/social problem severity (adj. OR = 2.2; p < 0.01). While abstinent individuals had lower 12-month employment severity than heavy drinkers (adj. OR = 1.9; p < 0.01), low-risk drinkers did not differ from heavy drinkers. The drinking groups did not differ on 12-month medical problem severity.
conclusionsCompared to heavy drinkers, low-risk drinkers did as well as abstinent individuals for many of the outcomes important to health and addiction policy. Thus, an endpoint that allows low-risk drinking may be tenable for individuals undergoing alcohol specialty treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.