ArticleACS nano2012
Photonic gene circuits by optically addressable siRNA-Au nanoantennas.
Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Phase intensity nanoscope (PINE) opens long-time investigation windows of living matter.Nature communications · 2023Article
- Optical Penetration of Shape-Controlled Metallic Nanosensors across Membrane Barriers.Sensors (Basel, Switzerland) · 2023Article
- Intelligent Fusion Imaging Photonics for Real-Time Lighting Obstructions.Sensors (Basel, Switzerland) · 2022Article
- Dynamic observations of CRISPR-Cas target recognition and cleavage heterogeneities.Nanophotonics (Berlin, Germany) · 2022Article
- Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer.Nanophotonics (Berlin, Germany) · 2021Article
- Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity.Nanomaterials (Basel, Switzerland) · 2021Review
- Photoresponsive miR-34a/Nanoshell Conjugates Enable Light-Triggered Gene Regulation to Impair the Function of Triple-Negative Breast Cancer Cells.Nano letters · 2021Article
- Photothermal Intracellular Delivery Using Gold Nanodisk Arrays.ACS materials letters · 2020Article
- Changes in Optical Properties of Plasmonic Nanoparticles in Cellular Environments are Modulated by Nanoparticle PEGylation and Serum Conditions.Nanoscale research letters · 2016Article
- Article
- RNA as a stable polymer to build controllable and defined nanostructures for material and biomedical applications.Nano today · 2015Article
- Mapping photothermally induced gene expression in living cells and tissues by nanorod-locked nucleic acid complexes.ACS nano · 2014Article
- Quantifying spectral changes experienced by plasmonic nanoparticles in a cellular environment to inform biomedical nanoparticle design.Nanoscale research letters · 2014Article
- RNA-guided diagnostics and therapeutics for next-generation individualized nanomedicine.The Journal of clinical investigation · 2013Article
- Toward plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models.Systems biomedicine (Austin, Tex.) · 2013Article
- Selective light-triggered release of DNA from gold nanorods switches blood clotting on and off.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The precise perturbation of gene circuits and the direct observation of signaling pathways in living cells are essential for both fundamental biology and translational medicine. Current optogenetic technology offers a new paradigm of optical control for cells; however, this technology relies on permanent genomic modifications with light-responsive genes, thus limiting dynamic reconfiguration of gene circuits. Here, we report precise control of perturbation and reconfiguration of gene circuits in living cells by optically addressable siRNA-Au nanoantennas. The siRNA-Au nanoantennas fulfill dual functions as selectively addressable optical receivers and biomolecular emitters of small interfering RNA (siRNA). Using siRNA-Au nanoantennas as optical inputs to existing circuit connections, photonic gene circuits are constructed in living cells. We show that photonic gene circuits are modular, enabling subcircuits to be combined on-demand. Photonic gene circuits open new avenues for engineering functional gene circuits useful for fundamental bioscience, bioengineering, and medical applications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.