ArticleMolecular biology and evolution2012
Purifying selection modulates the estimates of population differentiation and confounds genome-wide comparisons across single-nucleotide polymorphisms.
Article in Molecular biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Preliminary analysis of the conserved Plasmodium falciparum k13 gene in Arbaminch and Mirab Abaya, Ethiopia.Malaria journal · 2025Article
- The Relative Roles of Selection and Drift in the Chaffinch Radiation (Aves:Ecology and evolution · 2025Article
- Mathematical constraints on a family of biodiversity measures via connections with Rényi entropy.Bio Systems · 2024Article
- Mathematical bounds on Shannon entropy given the abundance of the ith most abundant taxon.Journal of mathematical biology · 2023Article
- Complete Mitochondrial Genomes of FourBiology · 2023Article
- Evolutionary Genomics of a Subdivided Species.Molecular biology and evolution · 2022Article
- Mathematical constraints onPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Article
- On the heterozygosity of an admixed population.Journal of mathematical biology · 2020Article
- Article
- Bounding measures of genetic similarity and diversity using majorization.Journal of mathematical biology · 2018Article
- The Effect of Balancing Selection on Population Differentiation: A Study with HLA Genes.G3 (Bethesda, Md.) · 2018Article
- Mathematical Constraints onGenetics · 2017Article
- Article
- Identifying Genetic Signatures of Natural Selection Using Pooled Population Sequencing in Picea abies.G3 (Bethesda, Md.) · 2016Article
- Enhancing the mathematical properties of new haplotype homozygosity statistics for the detection of selective sweeps.Theoretical population biology · 2015Article
- The effects of purifying selection on patterns of genetic differentiation between Drosophila melanogaster populations.Heredity · 2015Article
- Upper bounds on FST in terms of the frequency of the most frequent allele and total homozygosity: the case of a specified number of alleles.Theoretical population biology · 2014Article
- Continental-scale footprint of balancing and positive selection in a small rodent (Microtus arvalis).PloS one · 2014Article
- Signatures of natural selection on genetic variants affecting complex human traits.Applied & translational genomics · 2013Article
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3 authors.
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Abstract
An improved understanding of the biological and numerical properties of measures of population differentiation across loci is becoming increasingly more important because of their growing use in analyzing genome-wide polymorphism data for detecting population structures, inferring the rates of migration, and identifying local adaptations. In a genome-wide analysis, we discovered that the estimates of population differentiation (e.g., F(ST), θ, and Jost's D) calculated for human single-nucleotide polymorphisms (SNPs) are strongly and positively correlated to the position-specific evolutionary rates measured from multispecies alignments. That is, genomic positions (loci) experiencing higher purifying selection (lower evolutionary rates) produce lower values for the degree of population differentiation than those evolving with faster rates. We show that this pattern is completely mediated by the negative effects of purifying selection on the minor allele frequency (MAF) at individual loci. Our results suggest that inferences and methods relying on the comparison of population differentiation estimates (F(ST), θ, and Jost's D) based on SNPs across genomic positions should be restricted to loci with similar MAFs and/or the rates of evolution in genome scale surveys.
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