Evidence map›Paper›PMID 22826240›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2012

Subunit sharing among high- and low-fidelity DNA polymerases.

Lance D Langston, Mike O'Donnell

Abstract readComment

In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Loss of Pol32, a subunit of DNA polymerases δ and ζ, leads to different patterns of genome stability than direct impairment of these individual polymerases.mBio · 2026
Article
The processivity factor Pol32 mediates nuclear localization of DNA polymerase delta and prevents chromosomal fragile site formation in Drosophila development.PLoS genetics · 2019
Article
Loss of Pol32 in Drosophila melanogaster causes chromosome instability and suppresses variegation.PloS one · 2015
Article
A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae.DNA repair · 2014
Article
The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Mutation research
Review

4 · The record

Corrections and comments

Comment on
Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ.2012

5 · Who and what money

Authors and funding

2 authors.

Lance D LangstonHoward Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.

Mike O'Donnell

Funding

BIOCHEMICAL MECHANISM OF DNA POLYMERASE III HOLOENZYMER01GM038839 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI O'DONNELL, MICHAEL E · 1988 to 2014

$2.9M

IN VIVO EXPRESSION OF SCHWANN CELL NA CHANNELR01GM039939 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, GING K · 1988 to 1990

–

Howard Hughes Medical InstituteNIGMS NIH HHS GM39939NIGMS NIH HHS R01 GM038839

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA-Directed DNA PolymeraseDNA, FungalDNA Polymerase IIISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNA-Directed DNA PolymeraseDNA, FungalDNA Polymerase IIIPOL31 protein, S cerevisiaePol32 protein, S cerevisiaeREV3 protein, S cerevisiaeREV7 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID22826240

DOI10.1073/pnas.1209533109

PMCPMC3412035

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.