ArticleThe Journal of physiology2012
New perspectives concerning feedback influences on cardiorespiratory control during rhythmic exercise and on exercise performance.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Exercise and Autonomic Cardiovascular Function-Insights From Spinal Cord-Injured Humans: A Narrative Review.Acta physiologica (Oxford, England) · 2026Review
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- Article
- Sex differences in blood pressure and inactive limb blood flow responses during dynamic leg exercise with increased inspiratory muscle work.Nagoya journal of medical science · 2022Article
- Ultrasound-assessed diaphragm dysfunction predicts clinical outcomes in hemodialysis patients.Scientific reports · 2022Article
- Contribution of Peripheral Chemoreceptors to Exercise Intolerance in Heart Failure.Frontiers in physiology · 2022Review
- Degradation of energy cost with fatigue induced by trail running: effect of distance.European journal of applied physiology · 2021Article
- Combined influence of inspiratory loading and locomotor subsystolic cuff inflation on cardiovascular responses during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Muscle sympathetic nerve activity during exercise.The journal of physiological sciences : JPS · 2019Review
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Exercise-induced quadriceps muscle fatigue in men and women: effects of arterial oxygen content and respiratory muscle work.The Journal of physiology · 2017Article
- An integrated view on the oxygenation responses to incremental exercise at the brain, the locomotor and respiratory muscles.European journal of applied physiology · 2016Review
- Critical Power: An Important Fatigue Threshold in Exercise Physiology.Medicine and science in sports and exercise · 2016Review
- Effect of exercise training on ventilatory efficiency in patients with heart disease: a review.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Review
- Neural Control of Breathing and CO2 Homeostasis.Neuron · 2015Review
- Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure.American journal of physiology. Heart and circulatory physiology · 2015Review
- Regulation of the renal sympathetic nerves in heart failure.Frontiers in physiology · 2015Review
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Pathophysiology of human ventilatory control.The European respiratory journal · 2014Review
- Blood pressure regulation II: what happens when one system must serve two masters--oxygen delivery and pressure regulation?European journal of applied physiology · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cardioaccelerator and ventilatory responses to rhythmic exercise in the human are commonly viewed as being mediated predominantly via feedforward 'central command' mechanisms, with contributions from locomotor muscle afferents to the sympathetically mediated pressor response. We have assessed the relative contributions of three types of feedback afferents on the cardiorespiratory response to voluntary, rhythmic exercise by inhibiting their normal 'tonic' activity in healthy animals and humans and in chronic heart failure. Transient inhibition of the carotid chemoreceptors during moderate intensity exercise reduced muscle sympathetic nerve activity (MSNA) and increased limb vascular conductance and blood flow; and reducing the normal level of respiratory muscle work during heavier intensity exercise increased limb vascular conductance and blood flow. These cardiorespiratory effects were prevented via ganglionic blockade and were enhanced in chronic heart failure and in hypoxia. Blockade of μ opioid sensitive locomotor muscle afferents, with preservation of central motor output via intrathecal fentanyl: (a) reduced the mean arterial blood pressure (MAP), heart rate and ventilatory responses to all steady state exercise intensities; and (b) during sustained high intensity exercise, reduced O(2) transport, increased central motor output and end-exercise muscle fatigue and reduced endurance performance. We propose that these three afferent reflexes - probably acting in concert with feedforward central command - contribute significantly to preserving O(2) transport to locomotor and to respiratory muscles during exercise. Locomotor muscle afferents also appear to provide feedback concerning the metabolic state of the muscle to influence central motor output, thereby limiting peripheral fatigue development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.