Evidence map›Paper›PMID 22826031›Full record

ArticleInfection2013

Variation in antibiotic prescriptions: is area deprivation an explanation? Analysis of 1.2 million children in Germany.

D Koller, F Hoffmann, W Maier, K Tholen, R Windt, G Glaeske

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Article in Infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. The Decline in Outpatient Antibiotic Use.Deutsches Arzteblatt international · 2020
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  20. Outpatient Antibiotic Prescription.Deutsches Arzteblatt international · 2016
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

D KollerCentre for Social Policy Research, University of Bremen, UNICOM-Gebäude, Mary-Somerville-Str. 5, 28359, Bremen, Germany. dkoller@zes.uni-bremen.de
F Hoffmann
W Maier
K Tholen
R Windt
G Glaeske

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeInadequate use of antibiotics can lead to problems such as resistance. Overuse is especially a problem for children, since they are more affected by acute (often virus-caused) infections. While the problem has been addressed internationally over the past several years, regional variations in prescriptions are striking. Therefore, the present study aims to analyze regional variations in antibiotic prescription on a district level in Germany and tries to identify reasons for those variations through adding possible influencing factors to the analysis on individual and district levels.

methodsWe analyzed 1.2 million children insured in a German health insurance fund. Antibiotic prescriptions were quantified in 2010 and reasons for prescriptions were analyzed in multilevel regressions based on the district of residence, regional deprivation, and age and sex of the child.

resultsThirty-six percent of all children aged 0-17 years received an antibiotic prescription in 2010. In the south, prevalences are generally lower, and also to the very north. The highest prevalences are found in the close-to-border districts in the west, as well as in a band throughout the middle of Germany, in rather low population density areas. Regional variation in the prevalence range from 19 to 53 % between districts. Regional deprivation can explain part of this variation.

conclusionsIncluding area deprivation measures helped identify an influence of especially regional income and occupational deprivation on antibiotic prescriptions for children. Regional analysis such as this can help identify specific regions and groups of persons to address information programs on the risks of preventable antibiotic consumption and alternative treatment methods.

Indexed as

Anti-Bacterial AgentsAdolescentChildChild, PreschoolDrug PrescriptionsFemaleGeography, MedicalGermanyHumansInfantInfant, NewbornMaleModels, StatisticalAnti-Bacterial Agents

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.