ArticleJournal of materials science. Materials in medicine2012
Polyethylenimine functionalized magnetic nanoparticles as a potential non-viral vector for gene delivery.
Article in Journal of materials science. Materials in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Plasmid-DNA Delivery by Covalently Functionalized PEI-SPIONs as a Potential 'Magnetofection' Agent.Molecules (Basel, Switzerland) · 2022Article
- Functional Nanoparticles for Enhanced Cancer Therapy.Pharmaceutics · 2022Review
- Decrease in membrane fluidity and traction force induced by silica-coated magnetic nanoparticles.Journal of nanobiotechnology · 2021Article
- Effect of silica-coated magnetic nanoparticles on rigidity sensing of human embryonic kidney cells.Journal of nanobiotechnology · 2020Article
- In Vitro Evaluation of Lipopolyplexes for Gene Transfection: Comparing 2D, 3D and Microdroplet-Enabled Cell Culture.Molecules (Basel, Switzerland) · 2020Article
- Improving Magnetofection of Magnetic Polyethylenimine Nanoparticles into MG-63 Osteoblasts Using a Novel Uniform Magnetic Field.Nanoscale research letters · 2019Article
- Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances.ACS applied materials & interfaces · 2016Review
- Silica encapsulation of ferrimagnetic zinc ferrite nanocubes enabled by layer-by-layer polyelectrolyte deposition.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia.Journal of materials science. Materials in medicine · 2014Article
- Functional magnetic nanoparticles for non-viral gene delivery and MR imaging.Pharmaceutical research · 2014Review
- Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.Nanomedicine (London, England) · 2014Article
- Article
- Magnetofection: a reproducible method for gene delivery to melanoma cells.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyethylenimine (PEI) functionalized magnetic nanoparticles were synthesized as a potential non-viral vector for gene delivery. The nanoparticles could provide the magnetic-targeting, and the cationic polymer PEI could condense DNA and avoid in vitro barriers. The magnetic nanoparticles were characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction, dynamic light scattering measurements, transmission electron microscopy, vibrating sample magnetometer and atomic force microscopy. Agarose gel electrophoresis was used to asses DNA binding and perform a DNase I protection assay. The Alamar blue assay was used to evaluate negative effects on the metabolic activity of cells incubated with PEI modified magnetic nanoparticles and their complexes with DNA both in the presence or absence of an external magnetic field. Flow cytometry and fluorescent microscopy were also performed to investigate the transfection efficiency of the DNA-loaded magnetic nanoparticles in A549 and B16-F10 tumor cells with (+M) or without (-M) the magnetic field. The in vitro transfection efficiency of magnetic nanoparticles was improved obviously in a permanent magnetic field. Therefore, the magnetic nanoparticles show considerable potential as nanocarriers for gene delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.