ArticleThe Journal of biological chemistry2012
The AT-rich DNA-binding protein SATB2 promotes expression and physical association of human (G)γ- and (A)γ-globin genes.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination.Nature communications · 2026Article
- Article
- Paternal nicotine taking elicits heritable sex-specific phenotypes that are mediated by hippocampal Satb2.Molecular psychiatry · 2022Article
- Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Transcriptional regulation ofFrontiers in cell and developmental biology · 2022Article
- SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance.eLife · 2021Article
- SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes.The EMBO journal · 2021Article
- SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.EMBO molecular medicine · 2020Article
- Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development.Nucleic acids research · 2020Article
- Review
- Genes encoding SATB2-interacting proteins in adult cerebral cortex contribute to human cognitive ability.PLoS genetics · 2019Article
- Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment.PLoS genetics · 2018Article
- CCCTC-binding factor inhibits breast cancer cell proliferation and metastasis via inactivation of the nuclear factor-kappaB pathway.Oncotarget · 2017Article
- Clinical and molecular consequences of disease-associated de novo mutations in SATB2.Genetics in medicine : official journal of the American College of Medical Genetics · 2017Article
- Satb2 determines miRNA expression and long-term memory in the adult central nervous system.eLife · 2016Article
- SMAR1 binds to T(C/G) repeat and inhibits tumor progression by regulating miR-371-373 cluster.Scientific reports · 2016Article
- SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone.Aging · 2016Article
- Decreased SATB2 expression is associated with metastasis and poor prognosis in human clear cell renal cell carcinoma.International journal of clinical and experimental pathology · 2015Article
- Disclosure of a structural milieu for the proximity ligation reveals the elusive nature of an active chromatin hub.Nucleic acids research · 2013Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix attachment region (MAR)-binding protein (MARBP) has profound influence on gene transcriptional control by tethering genes to the nuclear scaffold. MARBP SATB2 is recently known as a versatile regulator functioning in the differentiation of multiple cell types including embryonic stem cells, osteoblasts and immunocytes. Roles of SATB2 in erythroid cells and its working mechanism in orchestrating target gene expression are largely unexplored. We show here that SATB2 is expressed in erythroid cells and activates γ-globin genes by binding to MARs in their promoters and recruiting histone acetylase PCAF. Further analysis in higher-order chromatin structure shows that SATB2 affects physical proximity of human (G)γ- and (A)γ-globin promoters via self-association. We also found that SATB2 interacts with SATB1, which specifically activates ε-globin gene expression. Our results establish SATB2 as a novel γ-globin gene regulator and provide a glimpse of the differential and cooperative roles of SATB family proteins in modulating clustered genes transcription and mediating higher-order chromatin structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.