ArticleJournal of the American Society for Mass Spectrometry2012
Accelerated C-N bond formation in dropcast thin films on ambient surfaces.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The trial behind it
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Who cites it
43 citing papers in PubMed.
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- Mechanisms of ionization and of chemical reactions in charged microdroplets.Chemical science · 2025Review
- High-Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry.ChemPlusChem · 2025Article
- Microfluidic Thread-Based Analytical Platform for Reaction Screening Enabled by In Situ Thread Spray Mass Spectrometry.Analytical chemistry · 2025Article
- Visualizing partial solvation at the air-water interface.Chemical science · 2024Article
- Examining DNA Structures with In-droplet Hydrogen/Deuterium Exchange Mass Spectrometry.International journal of mass spectrometry · 2024Article
- Stereoselectivity in electrosprayed confined volumes: asymmetric synthesis of warfarin by diamine organocatalysts in microdroplets and thin films.RSC advances · 2024Article
- Two-dimensional isomer differentiation using liquid chromatography-tandem mass spectrometry with in-source, droplet-based derivatization.The Analyst · 2023Article
- In-droplet hydrogen-deuterium exchange to examine protein/peptide solution conformer heterogeneity.Rapid communications in mass spectrometry : RCM · 2023Article
- Reactive Paper Spray Ionization Mass Spectrometry for Rapid Detection of Estrogens in Cosmetics.Molecules (Basel, Switzerland) · 2023Article
- Solvent-pumped evaporation concentration on paper in linear and radial geometries.Biomicrofluidics · 2023Article
- Reaction nanoscopy of ion emission from sub-wavelength propanediol droplets.Nanophotonics (Berlin, Germany) · 2023Article
- Accelerated and Concerted Aza-Michael Addition and SuFEx Reaction in Microdroplets in Unitary and High-Throughput Formats.Angewandte Chemie (International ed. in English) · 2022Article
- Microdroplet-Mediated Radical Polymerization.ACS central science · 2022Article
- Accelerated synthesis of energetic precursor cage compounds using confined volume systems.Scientific reports · 2021Article
- Article
- Microdroplet Mass Spectrometry Enables Extremely Accelerated Pepsin Digestion of Proteins.Journal of the American Society for Mass Spectrometry · 2021Article
- Direct Liquid Extraction and Ionization Techniques for Understanding Multimolecular Environments in Biological Systems (Secondary Publication).Mass spectrometry (Tokyo, Japan) · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aza-Michael addition and the Mannich condensation occur in thin films deposited on ambient surfaces. The reagents for both C-N bond formation reactions were transferred onto the surface by drop-casting using a micropipette. The surface reactions were found to be much more efficient than the corresponding bulk solution-phase reactions performed on the same scale in the same acetonitrile solvent. The increase in rate of product formation in the thin film is attributed to solvent evaporation in the open air which results in reagent concentration and produces rate acceleration similar to that seen in evaporating droplets in desorption electrospray ionization. This thin film procedure has potential for the rapid synthesis of reaction products on a small scale, as well as allowing rapid derivatization of analytes to produce forms that are easily ionized by electrospray ionization. Analysis of the derivatized sample directly from the reaction surface through the use of desorption electrospray ionization is also demonstrated.
Identifiers
22825741What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.