ArticleReproductive sciences (Thousand Oaks, Calif.)2012
TLR-4-dependent and -independent mechanisms of fetal brain injury in the setting of preterm birth.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Maternal Psychotherapy Addressing Generational Stress is Associated with Lower Preterm Birth Risk: The Pforzheim Study.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023Article
- Maternal siRNA silencing of placental SAA2 mitigates preterm birth following intrauterine inflammation.Frontiers in immunology · 2022Article
- The tracking of lipopolysaccharide through the feto-maternal compartment and the involvement of maternal TLR4 in inflammation-induced fetal brain injury.American journal of reproductive immunology (New York, N.Y. : 1989) · 2019Article
- The Absence of TLR4 Prevents Fetal Brain Injury in the Setting of Intrauterine Inflammation.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Maternal-Fetal Conflict During Infection: Lessons From a Mouse Model of Placental Malaria.Frontiers in microbiology · 2019Article
- Placental malperfusion in response to intrauterine inflammation and its connection to fetal sequelae.PloS one · 2019Article
- Ascending Lipopolysaccharide-Induced Intrauterine Inflammation in Near-Term Rabbits Leading to Newborn Neurobehavioral Deficits.Developmental neuroscience · 2018Article
- Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation.Journal of neuroinflammation · 2017Article
- Maternal dendrimer-based therapy for inflammation-induced preterm birth and perinatal brain injury.Scientific reports · 2017Article
- Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development.American journal of obstetrics and gynecology · 2016Article
- Effects of Lipopolysaccharide and Progesterone Exposures on Embryonic Cerebral Cortex Development in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2016Article
- Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile.Journal of perinatal medicine · 2016Article
- Allostatic Load and Preterm Birth.International journal of molecular sciences · 2015Review
- Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech.Scientific reports · 2015Article
- A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury.EMBO molecular medicine · 2015Article
- Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function.Journal of neuroinflammation · 2014Article
- A novel molecular microbiologic technique for the rapid diagnosis of microbial invasion of the amniotic cavity and intra-amniotic infection in preterm labor with intact membranes.American journal of reproductive immunology (New York, N.Y. : 1989) · 2014Article
- Demystifying animal models of adverse pregnancy outcomes: touching bench and bedside.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In this study, we sought to assess how essential activation of toll-like receptor 4 (TLR-4) is to fetal brain injury from intrauterine inflammation. Both wild-type and TLR-4 mutant fetal central nervous system cells were exposed to inflammation using lipopolysaccharide in vivo or in vitro. Inflammation could not induce neuronal injury in the absence of glial cells, in either wild-type or TLR-4 mutant neurons. However, injured neurons could induce injury in other neurons regardless of TLR-4 competency. Our results indicate that initiation of neuronal injury is a TLR-4-dependent event, while propagation is a TLR-4-independent event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.