Evidence map›Paper›PMID 22825702›Full record

ReviewNature reviews. Neurology2012

The benefits of exercise training in multiple sclerosis.

Robert W Motl, Lara A Pilutti

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 157 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 14 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02440516 nacompletednot on this mapstarted 2016, after this paper: background citation

Standardized Comprehensive Two-month Ambulatory Neurorehabilitation Program for Patients With Multiple Sclerosis: a Randomized-controlled Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2016 to 2019Enrolled65ConditionsMultiple SclerosisArmsEarly treatment group, Late treatment group
NCT02870023 nacompletednot on this mapstarted 2016, after this paper: background citation

How Does Strength Training and Balance Training Affect Gait Function and Fatigue in Patients With Multiple Sclerosis?

TypeinterventionalSponsorUniversity of AarhusRan2016 to 2018Enrolled71ConditionsMultiple SclerosisArmsBalance training, Strength training
NCT04097418 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Effects of Aerobic Training on Motor and Cognitive Performances in Patients With MS: an Exploratory Study With Structural and Functional MRI

TypeinterventionalSponsorIRCCS San RaffaeleRan2015 to 2024Enrolled80ConditionsMultiple SclerosisArmsAerobic training compared to conventional motor training
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 14 syntheses or guidelines pooled it, 390 citations in OpenAlex.

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  12. Effect of exercise therapy on quality of life of patients with multiple sclerosis in Iran: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017
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  13. Exercise therapy for fatigue in multiple sclerosis.The Cochrane database of systematic reviews · 2015
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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Robert W MotlDepartment of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, 233 Freer Hall, Urbana, IL 61801, USA. robmotl@illinois.edu
Lara A Pilutti
University of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelination and neurodegeneration within the CNS. This damage of CNS structures leads to deficits of body functions, which, in turn, affect patient activities, such as walking, and participation. The pathogenesis and resulting consequences of MS have been described as concepts within the International Classification of Functioning, Disability and Health (ICF) model--an international standard to describe and measure health and disability. Evidence suggests that exercise training in people with MS has the potential to target and improve many of the components outlined in the ICF model. Although the body of research examining the effects of exercise training on depression, cognition and participatory outcomes is not sufficiently developed, some preliminary evidence is promising. Exercise training is proposed to affect inflammation, neurodegeneration, and CNS structures, but current evidence is limited. In this Review, we discuss evidence from clinical trials that suggests beneficial effects of exercise training on muscle strength, aerobic capacity and walking performance, and on fatigue, gait, balance and quality of life. Issues with current studies and areas of future research are highlighted.

Indexed as

Clinical Trials as TopicExercise TherapyHumansMultiple SclerosisMuscle StrengthPhysical FitnessQuality of Life

Identifiers

PMID22825702
OpenAlexW1984516218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.