ArticleTumori
A case-control study of the risk of cutaneous melanoma associated with three selenium exposure indicators.
Article in Tumori. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Exposure to Trace Elements and Risk of Skin Cancer: A Systematic Review of Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2018Pooled it
- A review of dietary selenium intake and selenium status in Europe and the Middle East.Nutrients · 2015Pooled it
- Selenium for preventing cancer.The Cochrane database of systematic reviews · 2014Pooled it
- Nutrition and Diet Patterns as Key Modulators of Metabolic Reprogramming in Melanoma Immunotherapy.Journal of clinical medicine · 2025Review
- Review
- Scientific opinion on the tolerable upper intake level for selenium.EFSA journal. European Food Safety Authority · 2023Article
- Tapwater Exposures, Effects Potential, and Residential Risk Management in Northern Plains Nations.ACS ES&T water · 2022Article
- Serum Selenium Level and 10-Year Survival after Melanoma.Biomedicines · 2021Article
- An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: The case for adequate selenium status.Nutrition (Burbank, Los Angeles County, Calif.) · 2021Observational
- Toenails as biomarker of exposure to essential trace metals: A review.Environmental research · 2019Review
- Environmental Selenium and Human Health: an Update.Current environmental health reports · 2018Review
- A selenium species in cerebrospinal fluid predicts conversion to Alzheimer's dementia in persons with mild cognitive impairment.Alzheimer's research & therapy · 2017Article
- Longitudinal Association between Selenium Levels and Hypertension in a Rural Elderly Chinese Cohort.The journal of nutrition, health & aging · 2016Article
- Urgent need to reevaluate the latest World Health Organization guidelines for toxic inorganic substances in drinking water.Environmental health : a global access science source · 2015Review
- Scientific Opinion on Dietary Reference Values for selenium.EFSA journal. European Food Safety Authority · 2014Article
- Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.Neurotoxicology · 2013Article
- The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese.Archives of gerontology and geriatricsArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
AIMS AND
backgroundA direct association between exposure to the metalloid selenium and risk of cutaneous melanoma has been suggested by some observational and experimental cohort studies, whereas other studies have yielded inconsistent results. Since some of the inconsistencies may be due to exposure misclassification arising from the use of exposure indicators that do not adequately reflect body tissue selenium content or the levels of the biologically relevant species of this metalloid, we examined this issue using multiple indicators of exposure.
methodsWe analyzed the relation of selenium exposure with risk of cutaneous melanoma using two different biomarkers, plasma and toenail selenium concentration, and estimated dietary selenium intake in a population-based case-control series (54 cases, 56 controls) from an Italian community.
resultsIn unmatched and matched logistic regression models as well as nonparametric generalized additive models, higher plasma selenium levels were strongly associated with excess disease risk. In contrast, toenail and dietary selenium exhibited little relation with melanoma risk. The pattern of correlation among indicators of exposure differed by disease status, with dietary intake associated with plasma selenium levels in patients but not in controls.
conclusionsOur data showed that different selenium exposure indicators can yield different inferences about melanoma risk. Although the series was small, our results are consistent with a positive association between circulating levels of selenium and melanoma risk. Further investigation of the exposure classification performance of various selenium biomarkers and of metabolic patterns of the metalloid and of its speciation are needed to help elucidate the relation between selenium exposure and human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.