ArticleInfection and immunity2012
Stressor-induced increase in microbicidal activity of splenic macrophages is dependent upon peroxynitrite production.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals.Antioxidants (Basel, Switzerland) · 2023Review
- Psychological stress creates an immune suppressive environment in the lung that increases susceptibility of aged mice toFrontiers in cellular and infection microbiology · 2022Article
- A high-performance genetically encoded fluorescent biosensor for imaging physiological peroxynitrite.Cell chemical biology · 2021Article
- Beyond the neuro-immune interplay in depression: Could gut microbes be the missing link?Brain, behavior, & immunity - health · 2021Article
- Unique maternal immune and functional microbial profiles during prenatal stress.Scientific reports · 2020Article
- Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts.Frontiers in immunology · 2020Article
- Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells.Scientific reports · 2018Article
- Repeated Stress Exaggerates Lipopolysaccharide-Induced Inflammatory Response in the Rat Spleen.Cellular and molecular neurobiology · 2018Article
- Exposure to a Social Stressor Induces Translocation of Commensal Lactobacilli to the Spleen and Priming of the Innate Immune System.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- The role of the commensal microbiota in adaptive and maladaptive stressor-induced immunomodulation.Hormones and behavior · 2017Review
- Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGEScientific reports · 2016Article
- The N-B Interaction through a Water Bridge: Understanding the Chemoselectivity of a Fluorescent Protein Based Probe for Peroxynitrite.Journal of the American Chemical Society · 2016Article
- Social stress-enhanced severity of Citrobacter rodentium-induced colitis is CCL2-dependent and attenuated by probiotic Lactobacillus reuteri.Mucosal immunology · 2016Article
- Reactive nitrogen species in cellular signaling.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota.BMC microbiology · 2014Article
- Article
- Role of oxidative stress in infectious diseases. A review.Folia microbiologica · 2013Review
- Antioxidant Constituents of Cotoneaster melanocarpus Lodd.Antioxidants (Basel, Switzerland) · 2013Article
- Impact of stressor exposure on the interplay between commensal microbiota and host inflammation.Gut microbesReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Exposing mice to a social stressor called social disruption (SDR) that involves repeated social defeat during intermale aggression results in increased circulating cytokines, such as interleukin-1α (IL-1α) and IL-1β, and increased reactivity of splenic CD11b(+) macrophages to inflammatory stimuli. For example, upon lipopolysaccharide stimulation, macrophages from stressor-exposed mice produce higher levels of cytokines than do cells from nonstressed controls. Moreover, the SDR stressor enhances the ability of these macrophages to kill Escherichia coli both in vitro and in vivo, through a Toll-like receptor 4-dependent mechanism. The present study tested the hypothesis that stressor-enhanced bacterial killing is due to increases in the production of peroxynitrite. Male mice were exposed to the SDR stressor or were left undisturbed. Upon stimulation with E. coli, splenic macrophages from SDR-exposed mice expressed significantly increased levels of inducible nitric oxide synthase mRNA and produced higher levels of peroxynitrite. Blocking the production of peroxynitrite abrogated the SDR-induced increase in microbicidal activity. Studies in IL-1 receptor type 1 knockout mice indicated that the increased microbicidal activity and peroxynitrite production was dependent upon IL-1 signaling. These data confirm and extend the importance of IL-1 signaling for stressor-induced immunopotentiation; the finding that inhibiting superoxide or nitric oxide production inhibits both peroxynitrite production and killing of E. coli demonstrates that peroxynitrite mediates the stressor-induced increase in bacterial killing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.