ArticleInfection and immunity2012
Coagulases as determinants of protective immune responses against Staphylococcus aureus.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 78 citations in OpenAlex.
- Structural basis for the procoagulant activity ofBiological chemistry · 2026Review
- Enhancement of biodegradation capacity of microbial consortium in non-thermal plasma post-discharge for the removal of azo dye Reactive Red 120.Biodegradation · 2026Article
- Antibacterial and antibiofilm activity of platelet-rich plasma under different activation conditions against multidrug-resistant MRSA isolated from human skin abscesses.BMC biotechnology · 2025Article
- Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in Staphylococcus aureus Infection.The Journal of infectious diseases · 2025Article
- The Epistemology of Bacterial Virulence Factor Characterization.Microorganisms · 2024Review
- Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300.PLoS genetics · 2024Article
- Sub-MIC streptomycin and tetracycline enhancedBiofilm · 2023Article
- Surviving a sticky situation: therapeutic administration of fibrinogen variant γ' improves outcomes of Staphylococcus aureus septicemia.Journal of thrombosis and haemostasis : JTH · 2023Article
- Antibodies to coagulase ofFrontiers in immunology · 2023Article
- DNA and histones impair the mechanical stability and lytic susceptibility of fibrin formed by staphylocoagulase.Frontiers in immunology · 2023Article
- Phage display for the detection, analysis, disinfection, and prevention ofSmart medicine · 2022Review
- Virulence Genes of Staphylococcus aureus Associated With Keratitis, Conjunctivitis, and Contact Lens-Associated Inflammation.Translational vision science & technology · 2022Article
- Article
- Host fibrinogen drives antimicrobial function inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genome-Wide Analysis ofFrontiers in microbiology · 2020Article
- Functional Prediction and Assignment ofFrontiers in genetics · 2020Article
- Interaction of host and Staphylococcus aureus protease-system regulates virulence and pathogenicity.Medical microbiology and immunology · 2019Review
- Quercetin protects rats from catheter-related Staphylococcus aureus infections by inhibiting coagulase activity.Journal of cellular and molecular medicine · 2019Article
- Recent advances inInfection and drug resistance · 2019Review
- The Complex Fibrinogen Interactions of theFrontiers in cellular and infection microbiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
During infection, Staphylococcus aureus secretes two coagulases (Coa and von Willebrand factor binding protein [vWbp]), which, following an association with host prothrombin and fibrinogen, form fibrin clots and enable the establishment of staphylococcal disease. Within the genomes of different S. aureus isolates, coagulase gene sequences are variable, and this has been exploited for a classification of types. We show here that antibodies directed against the variable prothrombin binding portion of coagulases confer type-specific immunity through the neutralization of S. aureus clotting activity and protection from staphylococcal disease in mice. By combining variable portions of coagulases from North American isolates into hybrid Coa and vWbp proteins, a subunit vaccine that provided protection against challenge with different coagulase-type S. aureus strains in mice was derived.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.