ArticleHypertension (Dallas, Tex. : 1979)2012
Effect of pregnancy on autoregulation of cerebral blood flow in anterior versus posterior cerebrum.
Article in Hypertension (Dallas, Tex. : 1979), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Cerebral hyperemia measured with near infrared spectroscopy during treatment of diabetic ketoacidosis in children.The Journal of pediatrics · 2013Trial
- Aggregated postpartum cerebral autoregulatory curves in normotensive individuals, preeclampsia with severe features, and superimposed preeclampsia with severe features.Physiological measurement · 2025Observational
- Stroke vs. Preeclampsia: Dangerous Liaisons of Hypertension and Pregnancy.Medicina (Kaunas, Lithuania) · 2023Review
- Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia.Pregnancy hypertension · 2023Article
- Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia?Physiological reports · 2022Review
- Acute Intracranial Hypertension During Pregnancy: Special Considerations and Management Adjustments.Neurocritical care · 2022Review
- Cerebral Blood Flow Autoregulation in Offspring From Experimentally Preeclamptic Rats and the Effect of Age.Frontiers in physiology · 2022Article
- Neurovascular dysfunctions in hypertensive disorders of pregnancy.Metabolic brain disease · 2021Review
- Interleukin-17 induces hypertension but does not impair cerebrovascular function in pregnant rats.Pregnancy hypertension · 2021Article
- Endothelial cell disruption drives increased blood-brain barrier permeability and cerebral edema in the Dahl SS/jr rat model of superimposed preeclampsia.American journal of physiology. Heart and circulatory physiology · 2021Article
- Cerebral Blood Flow Regulation in Pregnancy, Hypertension, and Hypertensive Disorders of Pregnancy.Brain sciences · 2019Review
- Preeclampsia and Cerebrovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Maternal Stroke: an Update.Current atherosclerosis reports · 2019Review
- Peripheral Anti-Angiogenic Imbalance during Pregnancy Impairs Myogenic Tone and Increases Cerebral Edema in a Rodent Model of HELLP Syndrome.Brain sciences · 2018Article
- Impaired function of cerebral parenchymal arterioles in experimental preeclampsia.Microvascular research · 2018Article
- Article
- Effect of hypertension and peroxynitrite decomposition with FeTMPyP on CBF and stroke outcome.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Preeclampsia and the brain: neural control of cardiovascular changes during pregnancy and neurological outcomes of preeclampsia.Clinical science (London, England : 1979) · 2016Review
- Placental ischemia-induced increases in brain water content and cerebrovascular permeability: role of TNF-α.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Cytotoxic Edema in Posterior Reversible Encephalopathy Syndrome: Correlation of MRI Features with Serum Albumin Levels.AJNR. American journal of neuroradiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Severe preeclampsia and eclampsia are associated with brain edema that forms preferentially in the posterior cerebral cortex possibly because of decreased sympathetic innervation of posterior cerebral arteries and less effective autoregulation during acute hypertension. In the present study, we examined the effect of pregnancy on the effectiveness of cerebral blood flow autoregulation using laser Doppler flowmetry and edema formation by wet:dry weight in acute hypertension induced by phenylephrine infusion in the anterior and posterior cerebrum from nonpregnant (n=8) and late-pregnant (n=6) Sprague-Dawley rats. In addition, we compared the effect of pregnancy on sympathetic innervation by tyrosine hydroxylase staining of posterior and middle cerebral arteries (n=5-6 per group) and endothelial and neuronal NO synthase expression using quantitative PCR (n=3 per group). In nonpregnant animals, there was no difference in autoregulation between the anterior and posterior cerebrum. However, in late-pregnant animals, the threshold of cerebral blood flow autoregulation was shifted to lower pressures in the posterior cerebrum, which was associated with increased neuronal NO synthase expression in the posterior cerebral cortex versus anterior. Compared with the nonpregnant state, pregnancy increased the threshold of autoregulation in both brain regions that was related to decreased expression of endothelial NO synthase. Lastly, acute hypertension during pregnancy caused greater edema formation in both brain cortices that was not attributed to changes in sympathetic innervation. These findings suggest that, although pregnancy shifted the cerebral blood flow autoregulatory curve to higher pressures in both the anterior and posterior cortices, it did not protect from edema during acute hypertension.
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