ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Bone density and bone metabolism in patients with inflammatory bowel disease.
Article in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- A multilayered genetic structure analysis between inflammatory bowel disease and bone density/osteoporosis.PloS one · 2025Article
- The genetically predicted causal relationship of inflammatory bowel disease with bone mineral density and osteoporosis: evidence from two-sample Mendelian randomization.Frontiers in immunology · 2023Article
- Association of hemoglobin levels with bone mineral density for adults over 18 years of age: a cross-sectional study.Scientific reports · 2022Article
- Osteoporosis Complications in Crohn's Disease Patients: Factors, Pathogenesis, and Treatment Outlines.Cureus · 2021Review
- Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head-Preliminary Results.Animals : an open access journal from MDPI · 2021Article
- Vaccination and Health Maintenance Issues to Consider in Patients With Inflammatory Bowel Disease.Gastroenterology & hepatology · 2017Article
- Vitamin D Status and Bone Mineral Density in Children with Inflammatory Bowel Disease Compared to Those with Functional Abdominal Pain.Journal of Korean medical science · 2017Article
- Preventative Care in the Patient with Inflammatory Bowel Disease: What Is New?Digestive diseases and sciences · 2016Review
- Correlation between low bone density and disease activity in patients with ulcerative colitis.Middle East journal of digestive diseases · 2015Article
- Vitamin D deficiency and corticosteroid use are risk factors for low bone mineral density in inflammatory bowel disease patients.Digestive diseases and sciences · 2014Article
- Epidemiological and clinical characteristics of inflammatory bowel disease in patients from northwestern iran.Middle East journal of digestive diseases · 2013Article
- [The decrease in bone density in chronic inflammatory bowel disease: prevalence and risk factors].The Pan African medical journal · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND/
aimsPatients with inflammatory bowel disease (IBD) are at high risk for low bone mineral density (BMD). This study aimed to evaluate BMD in IBD patients and its relationship with bone metabolism in a group of Iranian patients. PATIENTS AND
methodsA cross-sectional study was conducted on patients with IBD to assess BMD status and serum biochemical factors. After getting the demographic data from 200 patients, they were screened using dual-energy X-ray absorptiometry of the lumbar spine (L2-L4) and femoral neck for BMD status. Serum levels of calcium, phosphate, alkaline phosphatase (ALP), and 25-hydroxyvitamin D (25-OH vitamin D) were measured to assess the bone metabolism status.
resultsTwo hundred patients with IBD were enrolled in the study. One hundred and eighty three (91.5%) patients were identified as having ulcerative colitis (UC) and 17 (8.5%) as having Crohn's disease (CD). Based on the lumbar and femoral neck bone mass densitometry, 148 (74.4%) patients had low BMD at either lumbar spine or femoral neck. Of these, 100 patients (50.3%) were osteopenic and 48 patients (24.1%) were osteoporotic. A 58.6% and 61% of patients with UC had low BMD in the lumbar and femoral neck, respectively. These results for those with CD were 76.5% and 70.6%, respectively. The mean of femoral neck and lumbar T-scores in patients with UC were -1.14 and -1.38, and in patients with CD were -1.24 and -1.47, respectively (P > 0.05). The mean (±SD) levels for calcium (Ca) in UC and CD were in the normal range. The mean (±SD) levels of ALP and 25-OH vitamin D in both the groups were in the normal range, and in comparison between groups (UC and CD), no significant differences were observed (P = 0.20 for ALP and P = 0.44 for 25-OH vitamin D). In the assessment of correlation between biochemical markers and BMD, an inverse correlation between lumbar T-score and ALP or 25-OH vitamin D only in patients with UC was observed.
conclusionsThe high prevalence of low BMD in the Iranian population with IBD needs attention. The subclinical vitamin D deficiency may contribute to bone loss in IBD patients, which is more pronounced in patients with UC in this study because of the small population of patients with CD.
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