Evidence map›Paper›PMID 22824477›Full record

ReviewClinics in liver disease2012

The relevance of liver histology to predicting clinically meaningful outcomes in nonalcoholic steatohepatitis.

Mangesh R Pagadala, Arthur J McCullough

Abstract readReview
In one paragraph

Review in Clinics in liver disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  10. Fatty liver disease in persons with HIV infection.Topics in antiviral medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mangesh R PagadalaDepartment of Gastroenterology and Hepatology, Cleveland Clinic, OH 44195, USA. pagadam@ccf.org
Arthur J McCullough
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · US

Funding

Non Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2M
Combined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6M
Training Program in Academic GastroenterologyT32DK061917 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, GREGORY S. · 2002 to 2006
$795k
NIDDK NIH HHS 5 U01 DK 061732NIDDK NIH HHS T32 DK061917NIDDK NIH HHS T32 DK083251NIDDK NIH HHS U01 DK061732
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disease. Nonalcoholic steatohepatitis (NASH), the more severe form of NAFLD, has an increased risk for progression to cirrhosis. The available data suggest increased morbidity and mortality among those patients with advanced histologic severity such as NASH and fibrosis. Despite the lack of a universally accepted histologic definition of NAFLD and inconsistency among pathologists regarding histologic findings essential to the diagnosis of NASH, a few studies have identified specific histologic findings (particularly fibrosis regardless of stage) that are able to predict NAFLD-related mortality as being most important.

Indexed as

Disease ProgressionFatty LiverFemaleHumansLiver CirrhosisLiver TransplantationMaleMallory BodiesNon-alcoholic Fatty Liver DiseasePrognosisSeverity of Illness Index

Identifiers

PMID22824477
PMCPMC4176889
OpenAlexW1999235047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.