ReviewCurrent opinion in pharmacology2012
Regulation of cholesterol biosynthesis and cancer signaling.
Review in Current opinion in pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Lipid profile and risk of ovarian tumours: a meta-analysis.BMC cancer · 2020Pooled it
- Cholesterol Metabolism: An Ally in the Development and Progression of Cervical Cancer.International journal of molecular sciences · 2026Review
- Lipid metabolism in colorectal cancer: dual roles and statin therapy.Discover oncology · 2025Review
- Crosstalk between lipid metabolism and EMT: emerging mechanisms and cancer therapy.Molecular and cellular biochemistry · 2025Article
- Association between serum lipid and papillary thyroid cancer: a retrospective study in China.PeerJ · 2025Article
- Is STARD3 A New Biomarker for Breast Cancer?European journal of breast health · 2024Review
- Pretreatment Lipoprotein(a) as a Biomarker for EGFR Mutation and Prognosis in Lung Adenocarcinoma.International journal of general medicine · 2024Article
- The Impact of Modern Dietary Practices on Cancer Risk and Progression: A Systematic Review.Cureus · 2023Review
- Review
- Article
- Low blood levels of high-density lipoprotein (HDL) cholesterol are positively associated with cancer.Journal of cancer research and clinical oncology · 2022Article
- Association of lipid profile with obesity among breast cancer survivors: a cross-sectional study.Lipids in health and disease · 2022Article
- Tumor metabolic reprogramming in lung cancer progression.Oncology letters · 2022Review
- Pretreatment HDL-C and ApoA1 are predictive biomarkers of progression-free survival in patients with EGFR mutated advanced non-small cell lung cancer treated with TKI.Thoracic cancer · 2022Article
- Raman spectroscopy biochemical characterisation of bladder cancer cisplatin resistance regulated by FDFT1: a review.Cellular & molecular biology letters · 2022Review
- Advances in Management of Bladder Cancer-The Role of Photodynamic Therapy.Molecules (Basel, Switzerland) · 2022Review
- Targeting Nutrient Dependency in Cancer Treatment.Frontiers in oncology · 2022Review
- Homologous Recombination Pathway Alternation Predicts Prognosis of Colorectal Cancer With Chemotherapy.Frontiers in pharmacology · 2022Article
- Review
- Crosstalk between Statins and Cancer Prevention and Therapy: An Update.Pharmaceuticals (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.