ArticleLipids in health and disease2012
Bioactivity of Samsum ant (Pachycondyla sennaarensis) venom against lipopolysaccharides through antioxidant and upregulation of Akt1 signaling in rats.
Article in Lipids in health and disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Drug Discovery Potential of Insect-derived Compounds: A Review.Current drug discovery technologies · 2025Review
- Samsum ant venom protects against carbon tetrachloride-induced acute spleen toxicity in vivo.Environmental science and pollution research international · 2021Article
- Anti-inflammatory activities of arthropod peptides: a systematic review.The journal of venomous animals and toxins including tropical diseases · 2021Review
- Thymoquinone ameliorates Pachycondyla sennaarensis venom-induced acute toxic shock in male rats.BMC pharmacology & toxicology · 2019Article
- Samsum ant venom modulates the immune response and redox status at the acute toxic doseThe journal of venomous animals and toxins including tropical diseases · 2019Article
- Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats.Canadian journal of gastroenterology & hepatology · 2019Article
- Potential effects of samsum ant, Brachyponera sennaarensis, venom on TNF-α/NF-κB mediated inflammation in CCL4-toxicity in vivo.Lipids in health and disease · 2016Article
- Camel milk peptide improves wound healing in diabetic rats by orchestrating the redox status and immune response.Lipids in health and disease · 2015Article
- Article
- Antioxidant bioactivity of Samsum ant (Pachycondyla sennaarensis) venom protects against CCL₄-induced nephrotoxicity in mice.Oxidative medicine and cellular longevity · 2014Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed at investigating the oxidative stress ameliorating effect, lipids profile restoration, and the anti-inflammatory effect of Samsum Ant Venom (SAV) in induced endotoxemic male rats, injected with bacterial lipopolysaccharides (LPS).
resultsResults revealed that LPS significantly increased the oxidative stress indications in LPS-injected rats. A significant increase of both malondialdehyde (MDA), and advanced oxidative protein products (AOPP), as well as a significant suppression of glutathione were all detected. Treatment with 100 μg/kg dose of SAV significantly restored the oxidative stress normal indications and increased the total glutathione levels. Treatment of the LPS-rats with 100 μg/kg dose of SAV showed a clear anti-inflammatory function; as the histological architecture of the hepatic tissue was partially recovered, along with a valuable decrease in the leukocytes infiltrated the hepatic tissues. Treatment of some rat groups with 600 μg/kg dose of SAV after LPS injection induced a severe endotoxemia that resulted in very high mortality rates. SAV versus the effects of LPS on AKT1, Fas, TNF-α and IFN-γ mRNA expression. SAV was found to significantly lower Fas gene expression comparing to the LPS group and restore the level of IFN-γ mRNA expression to that of the control group.
conclusionIn conclusion, SAV, at the dose of 100 μg/kg body weight, maintained and restored the oxidative stability, the anti-inflammatory, and the hypolipidemic bioactivity in rats after induced disruption of these parameters by LPS injection. This improvement by SAV was mediated by upregulation of AKT1.
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