ArticleBMC genomics2012
A survey of putative secreted and transmembrane proteins encoded in the C. elegans genome.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
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- Three muscle-specific DAF-16/FOXO transcriptional targets activated by reduced insulin/IGF-1 signaling.G3 (Bethesda, Md.) · 2026Article
- Variation in Social Feeding Behaviors and Interactions AmongEcology and evolution · 2025Article
- Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.bioRxiv : the preprint server for biology · 2025Article
- Identification of intestinal mediators ofmBio · 2025Article
- Functional Characterization of ShK Domain-Containing Protein in the Plant-Parasitic NematodePlants (Basel, Switzerland) · 2024Article
- RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses inFrontiers in molecular biosciences · 2024Article
- Insights into3 Biotech · 2023Article
- Pathways that affect anterior morphogenesis inbioRxiv : the preprint server for biology · 2023Article
- Identification of broadly-conserved parasitic nematode proteins that activate immunity.Frontiers in parasitology · 2023Article
- TENT5 cytoplasmic noncanonical poly(A) polymerases regulate the innate immune response in animals.Science advances · 2022Article
- Article
- Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans.PLoS genetics · 2021Article
- Facets of Autophagy Based Unconventional Protein Secretion-The Road Less Traveled.Frontiers in molecular biosciences · 2020Review
- Comparative Analysis of the Adhesive Proteins of the Adult Stalked Goose Barnacle Pollicipes pollicipes (Cirripedia: Pedunculata).Marine biotechnology (New York, N.Y.) · 2019Article
- Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression.PLoS genetics · 2018Article
- The R148.3 Gene ModulatesG3 (Bethesda, Md.) · 2017Article
- PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory-Neuron Shape and Function in C. elegans.Cell reports · 2016Article
- Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundAlmost half of the Caenorhabditis elegans genome encodes proteins with either a signal peptide or a transmembrane domain. Therefore a substantial fraction of the proteins are localized to membranes, reside in the secretory pathway or are secreted. While these proteins are of interest to a variety of different researchers ranging from developmental biologists to immunologists, most of secreted proteins have not been functionally characterized so far.
resultsWe grouped proteins containing a signal peptide or a transmembrane domain using various criteria including evolutionary origin, common domain organization and functional categories. We found that putative secreted proteins are enriched for small proteins and nematode-specific proteins. Many secreted proteins are predominantly expressed in specific life stages or in one of the two sexes suggesting stage- or sex-specific functions. More than a third of the putative secreted proteins are upregulated upon exposure to pathogens, indicating that a substantial fraction may have a role in immune response. Slightly more than half of the transmembrane proteins can be grouped into broad functional categories based on sequence similarity to proteins with known function. By far the largest groups are channels and transporters, various classes of enzymes and putative receptors with signaling function.
conclusionOur analysis provides an overview of all putative secreted and transmembrane proteins in C. elegans. This can serve as a basis for selecting groups of proteins for large-scale functional analysis using reverse genetic approaches.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.