ArticleBMC genomics2012
Burkholderia pseudomallei transcriptional adaptation in macrophages.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Metabolomic profiling ofmSystems · 2025Article
- Comparison of immunogenicity of 17 Burkholderia mallei antigens and whole cell lysate using indirect ELISA.The Journal of veterinary medical science · 2025Article
- Article
- Transcriptional landscape ofMicrobial genomics · 2023Article
- Evaluating the Contribution of the Predicted Toxin-Antitoxin System HigBA to Persistence, Biofilm Formation, and Virulence in Burkholderia pseudomallei.Infection and immunity · 2022Article
- The NarX-NarL two-component system regulates biofilm formation, natural product biosynthesis, and host-associated survival in Burkholderia pseudomallei.Scientific reports · 2022Article
- The Burkholderia pseudomallei intracellular 'TRANSITome'.Nature communications · 2021Article
- Hijacking of the Host's Immune Surveillance Radars byFrontiers in immunology · 2021Review
- A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor.Virulence · 2020Article
- An Evolutionary Arms Race BetweenFrontiers in microbiology · 2020Review
- Transcriptome Analysis Reveals Unfolded Protein Response Was Induced During the Early Stage ofFrontiers in genetics · 2020Article
- Identification ofFrontiers in microbiology · 2020Article
- Evaluating the role of Burkholderia pseudomallei K96243 toxins BPSS0390, BPSS0395, and BPSS1584 in persistent infection.Cellular microbiology · 2019Article
- MarR Family Transcription Factors fromMicrobiology and molecular biology reviews : MMBR · 2019Review
- Melioidosis in Malaysia: Incidence, Clinical Challenges, and Advances in Understanding Pathogenesis.Tropical medicine and infectious disease · 2018Review
- Review
- Global Awakening of Cryptic Biosynthetic Gene Clusters in Burkholderia thailandensis.ACS chemical biology · 2017Article
- Involvement of L-selectin expression in Burkholderia pseudomallei-infected monocytes invading the brain during murine melioidosis.Virulence · 2017Article
- Article
- Strategies Used by Bacteria to Grow in Macrophages.Microbiology spectrum · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBurkholderia pseudomallei is a facultative intracellular pathogen of phagocytic and non-phagocytic cells. How the bacterium interacts with host macrophage cells is still not well understood and is critical to appreciate the strategies used by this bacterium to survive and how intracellular survival leads to disease manifestation.
resultsHere we report the expression profile of intracellular B. pseudomallei following infection of human macrophage-like U937 cells. During intracellular growth over the 6 h infection period, approximately 22 % of the B. pseudomallei genome showed significant transcriptional adaptation. B. pseudomallei adapted rapidly to the intracellular environment by down-regulating numerous genes involved in metabolism, cell envelope, motility, replication, amino acid and ion transport system and regulatory function pathways. Reduced expression in catabolic and housekeeping genes suggested lower energy requirement and growth arrest during macrophage infection, while expression of genes encoding anaerobic metabolism functions were up regulated. However, whilst the type VI secretion system was up regulated, expression of many known virulence factors was not significantly modulated over the 6hours of infection.
conclusionsThe transcriptome profile described here provides the first comprehensive view of how B. pseudomallei survives within host cells and will help identify potential virulence factors and proteins that are important for the survival and growth of B. pseudomallei within human cells.
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