ArticleAnalytical chemistry2012
Rapid, sensitive detection of neurotransmitters at microelectrodes modified with self-assembled SWCNT forests.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 101 citations in OpenAlex.
- Innovating carbon-based electrodes for direct neurochemical detection along the brain-immune axis.Current opinion in electrochemistry · 2025Article
- Nanomaterial-Based Sensing Systems to Detect Neuropharmaceutical Compounds and Neurotransmitters.Sensors (Basel, Switzerland) · 2025Review
- Accurate evaluation of diffusion coefficient for electroactive analytes in human serum samples using nitrogen-terminated sputtered carbon film electrode.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Article
- Carbon microelectrodes for the measurement of neurotransmitters with fast-scan cyclic voltammetry: methodology and applications.Frontiers in bioengineering and biotechnology · 2025Review
- Dopamine Measurement Using Engineered CNT-CQD-Polymer Coatings on Pt Microelectrodes.Sensors (Basel, Switzerland) · 2024Article
- Biomedical Applications of CNT-Based Fibers.Biosensors · 2024Review
- Significance of an Electrochemical Sensor and Nanocomposites: Toward the Electrocatalytic Detection of Neurotransmitters and Their Importance within the Physiological System.ACS nanoscience Au · 2023Review
- Structure and Dynamics of Adsorbed Dopamine on Solvated Carbon Nanotubes and in a CNT Groove.Molecules (Basel, Switzerland) · 2022Article
- High resolution voltammetric and field-effect transistor readout of carbon fiber microelectrode biosensors.Sensors & diagnostics · 2022Article
- Porous Carbon Nanofiber-Modified Carbon Fiber Microelectrodes for Dopamine Detection.ACS applied nano materials · 2022Article
- Amine-functionalized carbon-fiber microelectrodes for enhanced ATP detection with fast-scan cyclic voltammetry.Analytical methods : advancing methods and applications · 2021Article
- Review-Recent Advances in FSCV Detection of Neurochemicals via Waveform and Carbon Microelectrode Modification.Journal of the Electrochemical Society · 2021Article
- Influence of Geometry on Thin Layer and Diffusion Processes at Carbon Electrodes.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Polymer Modified Carbon Fiber Microelectrodes for Precision Neurotransmitter Metabolite Measurements.Journal of the Electrochemical Society · 2020Article
- Evaluation of electrochemical methods for tonic dopamine detectionTrends in analytical chemistry : TRAC · 2020Article
- Timed Electrodeposition of PEDOT:Nafion onto Carbon Fiber-Microelectrodes Enhances Dopamine Detection in Zebrafish Retina.Journal of the Electrochemical Society · 2020Article
- Optimization of graphene oxide-modified carbon-fiber microelectrode for dopamine detection.Analytical methods : advancing methods and applications · 2020Article
- Polymer-Modified Carbon Fiber Microelectrodes for Neurochemical Detection of Dopamine and Metabolites.ECS transactions · 2020Article
- Carbon Nanotube Yarn Microelectrodes Promote High Temporal Measurements of Serotonin Using Fast Scan Cyclic Voltammetry.Sensors (Basel, Switzerland) · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Carbon nanotube (CNT) modification of microelectrodes can result in increased sensitivity without compromising time response. However, dip coating CNTs is not very reproducible and the CNTs tend to lay flat on the electrode surface which limits access to the electroactive sites on the ends. In this study, aligned CNT forests were formed using a chemical self-assembly method, which resulted in more exposed CNT ends to the analyte. Shortened, carboxylic acid functionalized single-walled CNTs were assembled from a dimethylformamide (DMF) suspension onto a carbon-fiber disk microelectrode modified with a thin iron hydroxide-decorated Nafion film. The modified electrodes were highly sensitive, with 36-fold higher oxidation currents for dopamine using fast-scan cyclic voltammetry than bare electrodes and 34-fold more current than electrodes dipped in CNTs. The limit of detection (LOD) for dopamine was 17 ± 3 nM at a 10 Hz repetition rate and 65 ± 7 nM at 90 Hz. The LOD at 90 Hz was the same as a bare electrode at 10 Hz, allowing a 9-fold increase in temporal resolution without a decrease in sensitivity. Similar increases were observed for other cationic catecholamine neurotransmitters, and the increases in current were greater than for anionic interferents such as ascorbic acid and 3,4-dihydroxyphenylacetic acid (DOPAC). The CNT forest electrodes had high sensitivity at 90 Hz repetition rate when stimulated dopamine release was measured in Drosophila . The sensitivity, temporal resolution, and spatial resolution of these CNT forest modified disk electrodes facilitate enhanced electrochemical measurements of neurotransmitter release in vivo.
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Registered trials
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