ArticleAnatomy & cell biology2012
Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study.
Article in Anatomy & cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- The transient external granular layer in human foetal cerebellum: insights into neurogenesis, genetic regulation, and developmental disorders.Anatomy & cell biology · 2025Review
- Prefrontal cortical microglial transcriptome relates to mouse offspring executive function deficits after perinatal opioid exposure in a sex-dependent manner.Brain, behavior, and immunity · 2025Article
- Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice.Neurotoxicology · 2023Article
- Prenatal exposure to morphine impairs attention and impulsivity in adult rats.Psychopharmacology · 2021Article
- Association Between Prenatal Opioid Exposure and Neurodevelopmental Outcomes in Early Childhood: A Retrospective Cohort Study.Drug safety · 2021Article
- Article
- Opioids affect the fetal brain: reframing the detoxification debate.American journal of obstetrics and gynecology · 2019Article
- Brain growth in the NICU: critical periods of tissue-specific expansion.Pediatric research · 2018Article
- Brain Injury and Development in Preterm Infants Exposed to Fentanyl.The Annals of pharmacotherapy · 2015Article
- Buprenorphine, methadone, and morphine treatment during pregnancy: behavioral effects on the offspring in rats.Neuropsychiatric disease and treatment · 2015Article
- Do maternal opioids reduce neonatal regional brain volumes? A pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The toxic effects of morphine sulfate in the adult cerebral cortex and one-day neonatal cerebellum have been studied. This study was carried out to evaluate the effect of maternal morphine exposure during gestational and lactation period on the Purkinje cells and cerebellar cortical layer in 18- and 32-day-old mice offspring. Thirty female mice were randomly allocated into cases and controls. In cases, animals received morphine sulfate (10 mg/kg/body weight intraperitoneally) during the 7 days before mating, gestational day (GD 0-21) 18 or 32. The controls received an equivalent volume of saline. The cerebellum of six infants for each group was removed and each was stained with cresyl violet. Quantitative computer-assisted morphometric study was done on cerebellar cortex. The linear Purkinje cell density in both experimental groups (postnatal day [P]18, 23.40±0.5; P32, 23.45±1.4) were significantly reduced in comparison with the control groups (P18, 28.70±0.9; P32, 28.95±0.4) (P<0.05). Purkinje cell area, perimeter and diameter at apex and depth of simple lobules in the experimental groups were significantly reduced compared to the controls (P<0.05). The thickness of the Purkinje layer of the cerebellar cortex was significantly reduced in morphine treated groups (P<0.05). This study reveals that morphine administration before pregnancy, during pregnancy and during the lactation period causes Purkinje cells loss and Purkinje cell size reduction in 18- and 32-day-old infant mice.
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