ArticleAnatomy & cell biology2012
Differential expression levels of synaptophysin through developmental stages in hippocampal region of mouse brain.
Article in Anatomy & cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 18 citations in OpenAlex.
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- Safflower Yellow Improves Synaptic Plasticity in APP/PS1 Mice by Regulating Microglia Activation Phenotypes and BDNF/TrkB/ERK Signaling Pathway.Neuromolecular medicine · 2020Article
- Altered expression and localization of synaptophysin in developing cerebellar cortex of neonatal rats due to maternal diabetes mellitus.Metabolic brain disease · 2016Article
- The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury.Scientific reports · 2016Article
- Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions.Psychopharmacology · 2016Article
- Differential expression levels of synaptophysin through developmental stages in hippocampal region of mouse brain.Anatomy & cell biology · 2012Article
- Synaptogenesis in the Cerebellum of Offspring Born to Diabetic Mothers.Journal of pediatric neurosciencesReview
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2 authors at 1 institution in 1 country.
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Abstract
The formation of neural synapses according to the development and growth of neurite were usually studied with various markers. Of these markers, synaptophysin is a kind of synaptic protein located in the synaptic vesicle of neuron or neuroendocrine cell known to be distributed consistently in all neural synapses. The purpose of this study was to investigate differential expression levels and patterns of synaptic marker (synaptophysin) in the mouse hippocampal region according to the developmental stages of embryonic, neonatal, and adulthood respectively. In the embryonic and neonatal groups, synaptophysin immunofluorescence was almost defined to cornu ammonis subfields (CA1 and CA3) of hippocampus and subiculum proper in the hippocampal region. However in dentate gyrus, synaptophysin immunoreactivities were insignificant or absent in all developmental stages. In embryonic and neonatal hippocampus, the intensities of immunofluorescence were significantly different between molecular and oriens layers. Furthermore, those intensities were decreased considerably in both layers of neonatal group compared to embryonic. The results from this study will contribute to characterizing synaptogenic activities in the central nervous system through developmental stages.
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