ArticleThe Plant cell2012
A genome-wide regulatory framework identifies maize pericarp color1 controlled genes.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 87 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
87 citing papers in PubMed, 173 citations in OpenAlex.
- Comparative transcriptomics of anthocyanin accumulation in the pericarp of pigmented purple corn.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- SbC1, an R2R3-MYB transcription factor, specifically regulates anthocyanin accumulation in sorghum coleoptiles.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Transcriptome profiling of maize transcription factor mutants to probe gene regulatory network predictions.G3 (Bethesda, Md.) · 2025Article
- Maize unstable factor for orange1 encodes a nuclear protein that affects redox accumulation during kernel development.The Plant cell · 2024Article
- Evolutionary trajectory of transcription factors and selection of targets for metabolic engineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Molecular mechanisms underlying gene regulatory variation of maize metabolic traits.The Plant cell · 2024Article
- Beyond pathways: Accelerated flavonoids candidate identification and novel exploration of enzymatic properties using combined mapping populations of wheat.Plant biotechnology journal · 2024Article
- An ARF gene mutation creates flint kernel architecture in dent maize.Nature communications · 2024Article
- Article
- Genetic analysis of pericarp pigmentation variation in Corn Belt dent maize.G3 (Bethesda, Md.) · 2023Article
- An unconventional proanthocyanidin pathway in maize.Nature communications · 2023Article
- R3-MYB repressor Mybr97 is a candidate gene associated with the Anthocyanin3 locus and enhanced anthocyanin accumulation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Evolution and function of red pigmentation in land plants.Annals of botany · 2022Review
- Transcriptome profiles of yellowish-white and fuchsia colored flowers in the Rheum palmatum complex reveal genes related to color polymorphism.Plant molecular biology · 2022Article
- Maize Flavonoid Biosynthesis, Regulation, and Human Health Relevance: A Review.Molecules (Basel, Switzerland) · 2022Review
- Cis-regulatory sequences in plants: Their importance, discovery, and future challenges.The Plant cell · 2022Review
- Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize.Plant physiology · 2022Article
- Comparative transcriptome analysis ofPeerJ · 2022Article
- Functional Characterization of a Flavone Synthase That Participates in a Kumquat Flavone Metabolon.Frontiers in plant science · 2022Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCORRECTION.2016
- Erratum issuedFalcone Ferreyra, Lorena [corrected to Falcone Ferreyra, Maria Lorena]
Authors and funding
15 authors at 5 institutions in 3 countries.
Funding
Abstract
Pericarp Color1 (P1) encodes an R2R3-MYB transcription factor responsible for the accumulation of insecticidal flavones in maize (Zea mays) silks and red phlobaphene pigments in pericarps and other floral tissues, which makes P1 an important visual marker. Using genome-wide expression analyses (RNA sequencing) in pericarps and silks of plants with contrasting P1 alleles combined with chromatin immunoprecipitation coupled with high-throughput sequencing, we show here that the regulatory functions of P1 are much broader than the activation of genes corresponding to enzymes in a branch of flavonoid biosynthesis. P1 modulates the expression of several thousand genes, and ∼1500 of them were identified as putative direct targets of P1. Among them, we identified F2H1, corresponding to a P450 enzyme that converts naringenin into 2-hydroxynaringenin, a key branch point in the P1-controlled pathway and the first step in the formation of insecticidal C-glycosyl flavones. Unexpectedly, the binding of P1 to gene regulatory regions can result in both gene activation and repression. Our results indicate that P1 is the major regulator for a set of genes involved in flavonoid biosynthesis and a minor modulator of the expression of a much larger gene set that includes genes involved in primary metabolism and production of other specialized compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.